Does the NEJM clinical trial discredit ivermectin?

In this video I note that the study design failed to take account of the hydrophobic nature of ivermectin, and the higher dose requirement to treat covid-19 than for treatment of parasites. This is because the covid target has different pharmacokinetics to the parasitic targets. I also present the argument the development of the Paxlovid covid antiviral may have been based upon the assumption of ivermectin efficacy. Paxlovid targets the same viral 3-chymotrypsin like protease enzyme that ivermectin inhibits. If cheap, safe and effective ivermectin is known to work, why develop new antivirals? I believe it is probably motivated by profit, and that is the reason that any information in favor of ivermectin's efficacy is discredited by the apparatus of power.