Berberine anti-aging effects

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Berberine is the primary compound extracted from Coptis chinensis and few other native Coptis species in some regions of China. For centuries, it has been used to treat diseases such as adult-onset diabetes. Berberine is known for its pharmacological effects on aging-related diseases which include but are not limited to hyperlipidemia, hyperglycemia, hypertension, arrhythmias, neuro-degeneration, depression, and anxiety. Recently, the potential mechanisms of berberine in combating aging and aging-related diseases have been attributed to AMPK activation in several cell types. AMPK activation serves as a cellular sensor that promotes autophagy through several mechanisms. The activation of AMPK in berberine is beneficial for cellular homeostasis and prevents the development of cell senescence. AMPK activation suppresses oxidative stress-induced senescence that is known to be the main cause of aging-related diseases. What happens when AMPK induces autophagy on cells? Autophagy is the process in which damaged macromolecules or organelles are removed. In aging, autophagy seems to be impaired, which is why senescent cells increase and aging-related diseases worsen as individual ages. AMPK activation also raises intracellular NAD+ concentration which activates SIRT1, the lonjèhvity gene.
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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, BERBERINE, AMPK, SIRT1.
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