What is NAD+ and its role on LONGEVITY

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Nicotinamide Adenine Dinucleotide is an essential coenzyme and substrate for a variety of proteins involved in multiple metabolic and cellular processes, such as DNA repair, cell cycle, and mitochondrial metabolism. It can be generated via two major pathway: de novo synthesis and salvage pathway. Through salvage pathway NAD is recycled from dietary niacin, consisting of NAM, NA, NR, and NMN. Because of the involvement of NAD+ in all these processes, its depletion could be one of the major contributors of different diseases, such as myocardial ischemia, cerebral ischemia, metabolic disorders, and glaucoma. Moreover, as we age the progressive functional decline is due to the accumulation of DNA mutations, and changes in metabolic rate and mitochondrial function. There is a growing evidence that NAD+ and its intermediates are greatly involved in controlling and slowing aging processess in humans. As we age NAD+ levels decrease in aging. According to Eduardo Chini and colleagues, a NADase, called CD-38 is the culprit of the decreasing amount of NAD+ and whose levels increase as we age. Several study suggest that treatment with precursors to N A D+ can have beneficial effects in health and can counteract many
diseases associeted with aging. In particular, several studies have demonstrated that NAD+
precursor supplementation that contains N-R improves mitochondrial function and activation
of sirtuins 1-7 Sirtuins 1-7 are N A D+ dependent enzymes involved in metabolic pathways and
in several biological processess, such as cell survival, apoptosis, D N A repair, cell
metabolism, and caloric restriction. Among these, sirtuin 1 is the most studied one,
for its neuroprotective action. In fact, it is an emerging therapeutic target for neurodegenerative
diseases, including Alzheimer’s disease, which is caused by Aβ plaque. Animals studies
have demonstrated that overexpression of N A D+ provides neuroprotective role. Another
important NAD+ precursor is N-A or niacin, which could be an effective supplement that
promotes lonjevity and muscle strength. It slows down aging through cell regeneration,
and its depletion has been suggested to promote aging and degenerative diseases.
It's important to talk to your doctor or other professional before beginning any sort of
supplementation or treatments. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, NAD+.

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