Age at menopause, mortality and NMN

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Age at menopause, mortality and NMN
In women, menopause is a reflection of the normal functioning of the hypothalamic-pituitary-ovarian axis, which affects the general health. Estrogen is produced in the ovaries between puberty and menopause. Low levels of estrogen are also produced in other organs such as breasts, liver, adrenal glands and other non-endocrine tissues. During menopause, the ovary no longer produces estrogen and progesterone, in response to the pituitary hormones, the follicle-stimulating hormone and luteinizing hormone. Estrogen may play a protective role against oxidative stress, inflammation and lipid and carbohydrate metabolism in skeletal muscle cell during the women reproductive age. Due to its role in the skeletal muscle, estrogen plays an essential role in maintenance of physical strength in aging women. When the levels of estrogen are diminished due to menopause, the physical strength of women undergoes a decline, which increases the risk of fall-related limb fractures. Estrogen may also play an important role in muscle repair and regenerative processess, although the mechanisms of action are still to be understood. Estrogen also plays an essential role the levels of antioxidant enzymes such as glutathione peroxidase, catalase, and superoxide dismutase. Estrogen also exhibits a protective role in the pathogenesis of cardiovascular diseases, including atherosclerosis, and this estrogen's role during menopause is significantly diminished. According to studies, low levels of estrogen during menopause lead to increased levels of L-D-L cholesterol and decreased levels of H-D-L, which causes the formation of atherosclerosis, a risk factor of cardiovascular diseases like stroke. It has been shown that 1 in women versus 1 in 6 mean at the age of 55 years will suffer a stroke event during their remaining lifetime. Due to the age-related pathologies and symptoms associated with menopause, the age of onset of menopause has been considered by researchers as a marker of lifespan. Studies say that early onset of menopause is associated with shorter lives. According to some studies, women can prevent the aging of ovaries and delay menopause in order to prevent the detrimental effects of estrogen deficiency that decreases the overall survival of women, through N-M-N supplementation. N-M-N treatment has been shown to decrease senescence marker in ovaries of mid-aged mice. Another study conducted in the University of Queensland in Australia and David a. Sinclair from Harvard have demonstrated the NMN, as a NAD + precursor, may restore and maintain female fertility during aging.

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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, LONGEVITY PROTOCOL.

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