HESPERIDIN --- Health benefits

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Hesperidin is a compound that belongs to the flavanone group of flavonoids, isolated from the rinds of some citrus species. Hesperidin has been reported to possess a wide range of biological activities that may promote health and treat certain conditions. Hesperidin has been reported to have anti-inflammatory and cardioprotective properties, although the exact mechanisms of action are still unknown. In a clinical study, 600 milligrams per day of hesperidin supplementation has significantly increased high-density lipoprotein cholesterol concentrations in patients with myocardial infarction. Moreover, the improvement in other inflammatory markers, such as interleukin 6, high sensitive C reactive protein, leptin and other lipid profile has been observed. In a recent study, hesperidin and its aglycone metabolite, hesperetin have been reported to be potential inhibitors against SARS-CoV-2 infection. Hesperidin and hesperetin have been shown to block the cellular entry of severe acute respiratory syndrome coronavirus 2 by binding two cellular receptors, angiotensin-converting enzyme 2 and transmembrane serine protease 2, which are required for the cellular entry of SARS-CoV-2 virus. By blocking these receptors, the cellular entry of the SARS CoV 2 variant regardless of the mutation of S protein can be inhibited. Hesperidin also possesses anti-obesity effect. According to a study, hesperidin regulates lipid metabolism and glucose metabolism by mediating A M P K and P P A R signaling pathways. AMPK activation has been shown to be a novel therapeutic strategy to treat and prevent obesity. It reduces insulin resistance and helps in burning fats, which promote weight loss effectively.

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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, LONGEVITY PROTOCOL.

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