Grape seed extract and aging|Grape seed extract and cell senescence/Grape seed extract as senolytic

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Grape seed extract and aging|Grape seed extract and cell senescence/Grape seed extract as senolytic
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Grapes are rich sources of vitamins and fibers that are known to possess potent health benefits. Grape seed extract is highly rich in polyphenols and flavonoids which have been reported to have a higher antioxidant activity compared to other well-known antioxidants such as vitamin C, vitamin E, and beta carotene. Grape seed extract contains other bioactive compounds responsible for its anti-inflammatory, anti-apoptotic, anti-necrotic, cardiovascular, and anti-carcinogenic activity. In a recent study, the procyanidin C 1 or PCC1 component of grape seed extract has been reported to increase the healthspan and lifespan through its senolytic activity. At low concentrations, PCC1 has been shown to inhibit senescence-associated secretory phenotype or SASP, which is a phenotype that characterizes senescent cells. Senescent cells are malfunctioning cells that accumulate with age. These cells release active substances that lead to damages in healthy cells. Moreover, they compromise tissue repair and regeneration, thus contributing to pathologies associated with aging. When greep seed extract is administered at higher concentrations, it has been reported to selectively kill senescent cells possibly by promoting production of reactive oxygen species and mitochondrial dysfunction. PCC1 has been identified as a natural senotherapeutic agent as a clinical intervention to delay, alleviate or prevent age related pathologies.
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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, LONGEVITY PROTOCOL.

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