Cycloastragenol

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Cycloastragenol
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Cycloastragenol is a triterpenoid found in legume species in the genus Astragalus that is now used as an oral anti-aging supplement. It has been demonstrated to stimulate telomerase activity and cell proliferation. Telomerase is a ribonucleoprotein complex that is responsible for synthesizing telomeres. Telomeres are D N A sequences located at the ends of chromosome which protect the D N A from degradation and damage. The length of telomeres shortenes with age, which is associated with aging, genome instability, and restriction of cell proliferation. Telomerase activity activation reverses the aging process and may rejuvenate premature aging-like diseases. Aside from cycloastragenol's ability to activate telomerase activity, it has been demonstrated to inhibit NLRP3 inflammasome activation in the pro-inflammatory macrophages. In mice, cycloastragenol has been shown to ameliorate imiquimod-induced psoriasiform dermatitis through its ability to inhibit NLRP3 inflammasome activation, thus decreasing the pro-inflammatory cytokines, including interleukin-6 and TNF-alpha. Specific pro-inflammatory cytokines are highly involved in the pathogenesis of chronic inflammatory conditions like dermatitis.
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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, LONGEVITY PROTOCOL.

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