Fecal microbiota transplant
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Fecal microbiota transplant
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Fecal microbiota transplant is a technique that consists of administering stool from a healthy donor to the colon of a recipient with a disease. This technique is done to restore the healthy fecal microbiome of the recipient, which can improve the recipient's health. Fecal microbiota transplant is currently used in treating recurrent Clostridium difficile infection. Clostridium difficile is a Gram-positive and toxin-producing bacillus that causes symptoms that range from wild watery diarrhea to potentially letal conditions such as pseudomembranous colitis. Aside from clostridium difficile infection, fecal microbiota transplant may also be applied in the treatment of other conditions including obesity, metabolic syndromes and even hallmarks of aging. In a study published in April 29, 2022, fecal microbiota transfer from young donor microbiota to aged mice has been shown to reverse the detrimental effects of aging gut, eye, and brain. Using fecal microbiota transplantation, the intestinal microbiota of young, old, and aged mice has been conducted. The changes in gut microbiota composition and metabolic potential have been analyzed alongside the effects of age and microbiota transfer on the gut barrier, retina, and the brain. The transfer of aged donor microbiota into young mice has accelerated age-associated central nervous system inflammation, retinal inflammation, and cytokine signaling and promote loss of key functional protein in the eye. The detrimental effects were then reversed by the transfer of young donor microbiota.
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