5-HTP and depression

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5-HTP and depression
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5-HTP is an intermediate metabolite of the essential amino acid L tryptophan in the biosynthesis of serotonin. 5-HTP crosses the blood-brain barrier and effectively increases central nervous system synthesis of serotonin. In the brain, adequate levels of serotonin have been linked to a series of psychiatric conditions including depression and chronic stress. For this reason, 5-HTP supplementation may provide some relief of depression due to its ability to increase serotonin levels. As a precursor of serotonin, it also reduces anxiety, sleep disorders and panic attacts. However, 5-HTP must not be taken alone because it depletes catecholamines including dopamine and norepinephrine. Depression is not only associated with serotonin dysfunction, but also with catecholamine dysfunction. So, it's important to have a properly balanced dopamine and serotonin amino acid precursors in treating depression.

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