Pre-eclampsia and dementia

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Pre-eclampsia and dementia
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Pre-eclampsia is a hypertensive disorder of pregnancy that is often characterized by hypertension and proteinuria during the third trimester. It is the most feared among the hypertensive disorders during pregnancy as it can rapidly progress to complications and stillbirth. Although this condition occurs during pregnancy, there are various clinical studies suggesting that it is associated with an increased risk of dementia later in life. Morever, they had greater brain atrophy and a trend towards a greater degree of white matter lesion volume. White matter contains axons which compose the neural connections between the lobes of the brain and spinal cord. White matter lesions are areas in the brain where abnormal myelination occurs. In a study published in the British Medical Journal in 2018, women who had hypertensive pregnancy disorder, like pre-eclampsia, perform more poorly on tests of processing speed decades after the hypertensive pregnancy. In the study, a cohort of all women in Denmark with at least one pregnancy lasting 20 weeks or longer and ending in live birth or stillbirth between 1978 and 2015 has been constructed using the civil registration system. Exempted from the study were those who died or emigrated before 1994. The results of the study revealed that women with a history of pre eclampsia had a 53% increase in risk of dementia overall, compared with women with no history of pre-eclampsia. The findings of the study may help physicians to identify a group of women who might benefit from early attention to modifiable vascular risk factors for dementia, such as concerted efforts to reduce blood pressure and blood cholesterol concentrations.
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