Baicalein in cancer and inflammations

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Baicalein in cancer and inflammations
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Baicalein is a flavonoid extract from the roots of Chinese herb, Scutellaria baicalensis. Baicalein has been found to have anti-cancer properties in different human carcinomas. It has inhibitory effects in angiogenesis, metastasis and inflammation in cancer. The anti-cancer properties of baicalein are mainly due to its ability to induce autophagy. Autophagy is a highly conserved evolutionary process that removes unnecessary and damaged organelles and proteins. Baicalein induces autophagy through its ability to activate AMPK pathway and inhibit mTOR or raptor complex 1 expression. Activation of AMPK pathway by baicalein further inhibits mTOR pathway. MTOR pathway is one of the most frequent mutated genes in cancer. It promotes cell proliferation and metabolism that contribute to tumor initiation and progression. Therefore, the inhibition of this pathway could prevent those mechanisms that promote cancer. Baicalein has also been shown to have anti inflammatory properties through its ability to enhance the activation of NRF2 and downregulate the activation of NLRP3 inflammasome and NF kappa B phosphorylation. Baicalein and its metabolite baicalin have been reported to ameliorate lupus autoimmunity. In a study conducted in 2019 by the group of Dr. Ji Yang, 4 weeks of treatment with baicalin has been shown to reduce 24 hour protein levels, relieved kidney inflammation and inhibit serum anti dsDNA antibody production.
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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, LONGEVITY PROTOCOL.Show more

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