Episode 12 - Contagion, Part 2: The Virus

Americanhardmind and Synchronicity discuss Contagion, including COVID-19 as we near the 2-year anniversary of a "pandemic". Part 2, The Virus includes:Show more

the Coronaviradae Family
Global Distribution of CVs
Zoonosis, or Cross-Species Contagion:

Su et al. (2016). Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends in Microbiology, 24(6): 490-502.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125511/pdf/main.pdf

Wong, Lau & Woo. (2019). Global Epidemiology of Bat Coronaviruses. Viruses, 11 (174): 1-17.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409556/pdf/viruses-11-00174.pdf

Genomics & Modification:

Andersen et al. (2020). The proximal origin of SARS-CoV-2. Nature Medicine, 26: 450-455. https://www.nature.com/articles/s41591-020-0820-9.pdf

Yan, Kang, Guan & Hu. (2020). Unusual features of the SARS-CoV-2 genome suggesting sophisticated laboratory modification rather than natural evolution and delineation of its probable synthetic route. 1-26.
https://mymilieuorg.files.wordpress.com/2020/09/sars-cov-2-synthetic-genome.pdf

Sorensen, Dalgleish & Susrud. (2020). A reconstructed historical aetiology of the SARS-CoV-2 spike. Oslo & London: 1-8.
https://www.minervanett.no/files/2020/07/13/TheEvidenceNoNaturalEvol.pdf

Letko, Marzi & Munster. (2020). Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nature Microbiology, 5: 562-575.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095430/pdf/41564_2020_Article_688.pdf

Xie et al. (2021). Engineering SARS-CoV-2 using a reverse genetic system. Nature Protocols. 1-24.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168523/pdf/nihms-1703791.pdf

Correction: Protospacer adjacent motif (PAM) not "proto adjacent mosaic".

The following is what to expect in Episode 13:
Education