Cranio-Cervical Instability (CCI)

Dr. Eric Gordon is interviewed by Dr. Saleeby on the topic of CCI. It includes a mention of MCAS, CDR (CDR1-3) Chronic Danger Response. Also touching on Mitochondrial impact and function. Brief discussion on Th1:Th2 and Th17.

How POTS, TCS, Chairi Malformation and CRPS figure in.

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In a study of 223 patients, the prevalence of the common comorbidities associated with EDS are reported as follows (1):

• Postural Orthostatic Tachycardia Syndrome (POTS) – 88%
• Mast Cell Activation Syndrome (MCAS) – 81%
• Tethered Cord Syndrome – 40%
• Chairi Malformation – 24%
• Craniocervical Instability (CCI) (21%)
• Complex Regional Pain Syndrome (CRPS) (20%)

There is a lot of symptom overlap with the comorbidities reported above. Of the same cohort of patients in the study, 52% of patients with EDS have symptoms suggestive of CCI when a Chiari malformation is present, and CCI is reported to nearly always occur with POTS and MCAS. [ref: https://www.physio-network.com/blog/upper-cervical-instability-hypermobility/]

Ref: (1) Brock, I., Chopra, P., Maitland, A., & Francomano, C. (2021). Frequency and co-occurrence of comorbidities in the Ehlers-Danlos syndromes. Molecular Genetics and Metabolism 132S1, S59-S198.

https://www.physio-network.com/blog/upper-cervical-instability-hypermobility/