Does Phosphatidic Acid WORK!?

Mediator PA, Phosphatidic ACID – Will it get you lean mass, more strength and help with fat loss? I break down what phosphatidic acid is, what the claims behind it are, and what the studies show.

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Phosphatidic Acid
• 500mg Mediator ® PA per capsule
• Enhances lean mass gains*
• Supports incresed strength*
• Encourages fat loss & body recomposition*
• Combats muscle breakdown*
• Promotes muscle recovery*

Phosphatidic acid Studied:
https://jissn.biomedcentral.com/articles/10.1186/s12970-016-0135-x
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506449/

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Does Phosphatidic Acid WORK!?
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#Benefits of Mediator PA
Increased Size & Strength
Research has shown that lifters taking phosphatidic acid (750mg/day = 1500mg Mediator PA):
• Increased their squat strength by 12.7%
• Increased lean body mass by 2.6%[1,2]
Fat Loss & Body Recomposition
Individuals supplementing with phosphatidic acid, in conjunction with resistance training, lost 2.8 pounds of body fat compared to only 1.1 pounds of fat loss for the control group.[2]
Aids Recovery
Muscle growth and recovery is ultimately a balance of protein synthesis vs protein breakdown.
In addition to stimulating protein synthesis, Phosphatidic Acid (PA) may help limit catabolism by reducing the expression of a set of genes that encourage muscle protein breakdown.[3]
High Bioavailability
Phosphatidic acid offers high bioavailability and has been shown to be efficiently absorbed and utilized in humans when taken orally (the same of which CANNOT be said for other “natural muscle building supplements”).[4]
High Safety Profile
Phosphatidic acid is natural and non-hormonal.
References
1. Hoffman JR, Stout JR, Williams DR, et al. Efficacy of phosphatidic acid ingestion on lean body mass, muscle thickness and strength gains in resistance-trained men. Journal of the International Society of Sports Nutrition. 2012;9:47. doi:10.1186/1550-2783-9-47.
2. Joy JM, Lowery RP, Dudeck JE, De-Souza EO, Jager R, McCleary , Wilson SMC, Purpura M, Wilson JM. Phosphatidic Acid Supplementation Increases Skeletal Muscle Hypertrophy and Strength. Poster presentation at the ISSN Conference 2013
3. Bond, P. (2017). Phosphatidic acid : biosynthesis , pharmacokinetics , mechanisms of action and effect on strength and body composition in resistance-trained individuals, 1–9. https://doi.org/10.1186/s12986-017-0166-6
4. Purpura M, Jager R, Joy JM, Lowery RP, Moore JD, Wilson JM. Effect of Oral Administration of Soy-Derived Phosphatidic ACid on Concentrations of Phosphatidic Acid and lyso-Phosphatidic Acid Molecular Species in Human Plasma. Poster Presentation at the ISSN Conference 2013.
5. Dudeck JE, Joy JM, Lowery RP, De Souza EO, Jager R, McCleary , Wilson SMC, Purpur M, Wilson JM. Safety of Soy-Derived Phosphatidic Acid Supplementation in Healthy Young Males. Poster presentation at the ISSN Conference 2013