4 years ago

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Supplements from the scientific literature that have proven to help improve schizophrenia outcomes. A follow up to "7 Supplements for Schizophrenia".

Full list of tips is on BlogSpot here:
https://schizoprevent.blogspot.com/

0:00 Intro
0:35 MethylFolate
7:02 Zinc
9:55 Sarcosine
13:41 L-Thianine
14:35 Lysine
15:00 Metformin, Statins, Calcium channel blockers
17:18 Conclusion

8 Supplements for Schizophrenia

MethylFolate (effects the turnover of monoamines including dopamine and saratonin, helping make them along with DNA, vascular system with homocysteine)
Red blood cell folate not serum level below 200 ug/1 entered the double-blind, placebo-controlled (31%to12%)
Half symptoms in the clinical rating scale
trial of treatment with methylfolate 15 mg daily for 6 months, 7.5mg a day is enough though

Not tested for low folate
FOLH1 484T/T works(A) and 484C carrier doesnt
10% after placebo 20% before

https://jamanetwork.com/journals/jamapsychiatry/article-abstract/1660588

10% effect supplement folic acid @2mg in those with high homocysteine

Side effects very rare

They now fortify foods with folate

Check google drive link for many of the scientific studies here:
https://drive.google.com/drive/folders/0B3eX0nlkVBRReXFXN2VpT0stQW8?usp=sharing

Zinc (NMDA) zinc definency in schizos
Zinc supplementation leads to 30% reduction in negative symptoms 30% reduction to positive symptoms 10% cognitive symptoms. Much lower aggresion score. It affects the nmda function, lowering it. And also helps with inflammation You can check out the study. They used 50mg zinc 3 times a day for 6 weeks. But that amount of zinc may cause problems could try 25-40mg a day. For 6 wks. Zinc can cause lower red blood cell counts so discontinue if u start getting light headed.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644625/

Sarcosine (NMDA)
15% improvement to PANSS scores negative
15% to total panss score after placebo
2g a day
One study showed 5% after placebo
positive cogitive depression scores
Antiaxiety fixed (as much as antiaxiety meds)
Ocd 20% help
Odd slightly helped
Hypomanic symptoms decreased need for sleep elevated libido and mood

https://selfhacked.com/blog/sarcosine/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632760

L-Thianine
200mg twice a day
Placebo
22 pos
26% neg
23% general

L thianine
33 pos
31 neg
30 general

250 once a day
10% effect no placebo was used for comparison

Quality of life went down slighly in both placebo and l thianine along with global functioning scores
L thiamine
helps schiz sleep and tinnitus increases gaba neurotransmitter plus nauroprotective plus effects glutemate NMDA receptor. Placebo had large effect too (but l thiamine was greater)-- power of belief. Found in green tea, there were no adverse side effects reported in either study.

Lysine
Better positive symptoms (likely not worth trying similar to placebo effect

biguanides (metformin) 27% reduction, 36% self harm

Statins, associated with 0.75 hazard ratio of getting hospilized in schizophrenia compared to those not taking them. (25% reduction, 45% reduction in self harm)

calcium channel blockers 20% reduction
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2719703

Tips:
Links in about section

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