Natural Killer Cells and Antibody Dependent Cellular Cytotoxicity (ADCC) German Study

Natural Killer Cells and Antibody Dependent Cellular Cytotoxicity (ADCC) German Study

A German study demonstrates how the natural killer cells of the innate arm kill the spike expressing cells through antibody dependent cellular cytotoxicity mechanism. This is also a form of antibody dependent enhancement (ADE). Let's review.

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URL list from Wednesday, Apr. 20 2022

Natural killer cell‐mediated ADCC in SARS‐CoV‐2‐infected individuals and vaccine recipients - Hagemann - - European Journal of Immunology - Wiley Online Library
https://onlinelibrary.wiley.com/doi/10.1002/eji.202149470

CD107a as a functional marker for the identification of natural killer cell activity - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0022175904002923#:~:text=CD107a%20is%20expressed%20at%20high,et%20al.%2C%202003).

NK Cells Activated through Antibody-Dependent Cell Cytotoxicity and Armed with Degranulation/IFN-γ Production Suppress Antibody-dependent Enhancement of Dengue Viral Infection | Scientific Reports
https://www.nature.com/articles/s41598-018-36972-2

Frontiers | Two Different Antibody-Dependent Enhancement (ADE) Risks for SARS-CoV-2 Antibodies | Immunology
https://www.frontiersin.org/articles/10.3389/fimmu.2021.640093/full