Medicines that Worsen Insulin Resistance (Do you take One?)

Which medications worsen Insulin Resistance? There is a long list! Make sure you're not taking one of these medicines that worsen insulin resistance. If you are, talk with your doctor about changing/decreasing/stopping them.

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-----Medications that worsen Insulin Resistance-----
Thiazides - HCT, HCTZ, indapamide
Beta blockers - metoprolol, propranolol, Atenolol
Antipsychotics 2nd gen - Abilify, Geodon, Seroquel, Zyprexa
fluoroquinolones - Levaquin, Cipro
corticosteroids - prednisone, methylprednisolone, prednisolone
Niacin - Rx and supplements
Diabetes medications
Amylin mimetics
pramlintide (SymlinPen).
Incretin mimetics
exenatide immediate-release (Byetta)
exenatide extended-release (Bydureon)
liraglutide (Victoza)
Dipeptidyl-peptidase 4 inhibitors
saxagliptin (Onglyza)
sitagliptin (Januvia)
linagliptin (Tradjenta)
GLP-1 Agonists
Byetta
Ozempic
Rybelsus
Trulicity
Victoza
Bydureon
Tanzeum
Sulfonylureas
glyburide (Micronase)
glipizide (Glucotrol)
glimepiride (Amaryl)
chlorpropamide (generic only in the United States)
tolazamide (generic only in United States)
tolbutamide (generic only in United States)
Glinides
nateglinide (Starlix)
repaglinide (Prandin)
ALL Injectable/Inhaled Insulins
Humulin, Novolin, Humulin, Novolog, Fiasp, Apidra, Myxredlin, Lantus, Toujeo, Basaglar, Semglee,
Levemir, Tresiba, Soiqua, Xutophy, Afrezza, Humalog, Admelog, Lyumjev

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Ken D Berry, MD, is a Family Physician and has been practicing Family Medicine in Tennessee for over 20 years, having seen over 25,000 patients in his career so far.
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