Ted Naiman 5: GLUCOSE OVERWHELMS MITOCHONDRIA...and they will not burn fat

Low Carb Down Under
Breckenridge, 2017

Metabolic flexibility...
-goes down to
mitochondrial level

Mitochondria have 2 inputs:
-glucose
-fat

Healthy ones can easily
-flex back & forth

2 inputs: glucose & fat
-excess glucose goes in
-produces citrate

-extra citrate tells body
"time to make fat"
-converts into malonyl-CoA
-BLOCKS CPT-1, so:
-fat can't enter mitochondria
to be burned

When you make fat;
you won't burn fat...

-fat re-routed as
triglycerides to be stored

Dump in glucose
-export citrate
-creates malonyl CoA
-block entry of fat
-so, fat accumulates as
triglycerides to be
stored

You don't want to be
making fat on one side
&
burning fat on the other...

FUTILE CYCLE

Study: measured oxidation
of glucose & fat in
mitochondria...

-infused participants with
glucose & insulin:

~glucose oxidation UP
~fat oxidation DOWN

This is why when you eat carbs
all day long...

you are not burning bodyfat

"Availability of glucose,
NOT fat,
is the main determinent of
the substrate:
either fat or glucose"

"Availability of glucose,
NOT fat,
is the main determinent of
the substrate:
either fat or glucose"

Dump in glucose...
Have to burn glucose!

Insulin binds to the cell:
-GLUT-4 transporter
goes to surface...
-brings glucose IN
-converted to malonyl CoA
-blocks CPT-1, so
~no fat burning!

Accumulated fat:
-shuts off insulin
signaling,
-GLUT-4 goes
back into cell

Your cell is...
-smarter than you!