Omicron Pathogenesis is Different - It Uses Two Ways To Enter A Cell (SARS-COV-3)
Omicron Science is Different - It Uses Two Ways To Enter A Cell (SARS-COV-3)
Researchers from Cambridge University UK shed light on the amazing mutations in Omicron that make it more transmissible but less damaging to the lung tissue. Let's review.
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Reference URL list from Monday, Jan. 3 2022
Media_829360_smxx.pdf
https://www.gla.ac.uk/media/Media_829360_smxx.pdf
SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with delta variant in TMPRSS2-expressed cells - PubMed
https://pubmed.ncbi.nlm.nih.gov/34951565/
Cathepsin - Wikipedia
https://en.wikipedia.org/wiki/Cathepsin
Green fluorescent protein - Wikipedia
https://en.wikipedia.org/wiki/Green_fluorescent_protein
Omicron may be significantly better at evading vaccine-induced immunity, but less likely to cause severe disease | University of Cambridge
https://www.cam.ac.uk/research/news/omicron-may-be-significantly-better-at-evading-vaccine-induced-immunity-but-less-likely-to-cause
SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion | bioRxiv
https://www.biorxiv.org/content/10.1101/2021.12.17.473248v2
‘Mini-lungs’ reveal early stages of SARS-CoV-2 infection | University of Cambridge
https://www.cam.ac.uk/research/news/mini-lungs-reveal-early-stages-of-sars-cov-2-infection
Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins - PubMed
https://pubmed.ncbi.nlm.nih.gov/32380510/
https://www.businessinsider.com/studies-omicron-less-severe-attacks-lung-cells-TMPRSS2-Gupta-COVID-2021-12
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Part 2 - Unvaccinated and Omicron (South Africa 4th Wave Data)
Part 2 - Unvaccinated and Omicron (South Africa 4th Wave Data)
A research letter from South Africa to JAMA shares the characteristics of the Omicron patients that were treated or admitted to hospitals in South Africa. Let's review the data especially in context of the unvaccinated individuals risk of severe disease and death.
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Reference URL list from Friday, Dec. 31 2021
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
Characteristics and Outcomes of Hospitalized Patients in South Africa During the COVID-19 Omicron Wave Compared With Previous Waves | Global Health | JAMA | JAMA Network
https://jamanetwork.com/journals/jama/fullarticle/2787776?guestAccessKey=919da83d-b6f9-4e05-8de1-05cca4541a59&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=123021
South Africa: Coronavirus Pandemic Country Profile - Our World in Data
https://ourworldindata.org/coronavirus/country/south-africa
South Africa COVID - Coronavirus Statistics - Worldometer
https://www.worldometers.info/coronavirus/country/south-africa/
https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-provide-update-omicron-variant
https://www.cnbc.com/2021/12/09/south-africa-omicron-crisis-cases-hospitalizations-and-vaccinations.html
https://www.medrxiv.org/content/10.1101/2021.12.20.21268096v1
https://www.theguardian.com/world/2021/dec/17/south-africa-says-vaccines-and-natural-immunity-are-limiting-latest-covid-wave
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Unvaccinated and Omicron (South Africa 4th Wave Data)
Unvaccinated and Omicron (South Africa 4th Wave Data)
A research letter from South Africa to JAMA shares the characteristics of the Omicron patients that were treated or admitted to hospitals in South Africa. Let's review the data especially in context of the unvaccinated individuals risk of severe disease and death.
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Reference URL list from Friday, Dec. 31 2021
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
Characteristics and Outcomes of Hospitalized Patients in South Africa During the COVID-19 Omicron Wave Compared With Previous Waves | Global Health | JAMA | JAMA Network
https://jamanetwork.com/journals/jama/fullarticle/2787776?guestAccessKey=919da83d-b6f9-4e05-8de1-05cca4541a59&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=123021
South Africa: Coronavirus Pandemic Country Profile - Our World in Data
https://ourworldindata.org/coronavirus/country/south-africa
South Africa COVID - Coronavirus Statistics - Worldometer
https://www.worldometers.info/coronavirus/country/south-africa/
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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US FDA Writes a Letter to Federation of State Medical Boards (FSMBs)
US FDA Writes a Letter to Federation of State Medical Boards (FSMBs)
US FDA is working hard to protect individuals from IVM. Let's review their letter dated December 13th 2021 to FSMBs.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Self Tolerance and Microbe Triggered Autoimmunity (B Cell Focus)
Self Tolerance and Microbe Triggered Autoimmunity (B Cell Focus)
We have been discussing the autoantibodies or anti-idiotype antibodies for a few days. A frequent question was that how does the immune system start attacking our own tissue while it was not doing so before the COVID infection or a Spike protein vaccine. Let's build our understanding of these mechanisms.
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Page 350. Anergy and the role of tissue resident dendritic cells.
Page 350. B cell tolerance. A beautiful mechanism of B cell receptor editing.
Page 351. B cell deletion by an unknown mechanism.
Normal mechanism is B cell anergy in the presence of abundant antigen from all sides of the immature B cell.
Immunologic tolerance is defined as unresponsiveness to an antigen that is induced by exposure to that antigen. The term arose from the experimental observation that animals that had encountered an antigen under particular conditions would not respond to, that is, would tolerate, subsequent exposures to the same antigen.
Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 337). Elsevier Health Sciences. Kindle Edition.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Self Tolerance and Microbe Triggered Autoimmunity (T Cell Focus)
Self Tolerance and Microbe Triggered Autoimmunity (T Cell Focus)
We have been discussing the autoantibodies or anti-idiotype antibodies for a few days. A frequent question was that how does the immune system start attacking our own tissue while it was not doing so before the COVID infection or a Spike protein vaccine. Let's build our understanding of these mechanisms.
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Page 350. Anergy and the role of tissue resident dendritic cells.
Page 350. B cell tolerance. A beautiful mechanism of B cell receptor editing.
Page 351. B cell deletion by an unknown mechanism.
Normal mechanism is B cell anergy in the presence of abundant antigen from all sides of the immature B cell.
Immunologic tolerance is defined as unresponsiveness to an antigen that is induced by exposure to that antigen. The term arose from the experimental observation that animals that had encountered an antigen under particular conditions would not respond to, that is, would tolerate, subsequent exposures to the same antigen.
Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 337). Elsevier Health Sciences. Kindle Edition.
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
6
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Autoimmune disease caused by spike protein and potential management approaches
Autoimmune disease caused by spike protein and potential management approaches
There is growing evidence that spike protein could result in anti-ACE2 antibodies. This in most cases is a normal (homeostatic) mechanism. However, in some individuals it can last longer and become problematic. Let's review the possible therapies in light of the pathogenesis. Educational material only. Not a medical advice. Please discuss these therapies with your doctor and follow his advice.
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Reference URL list from Tuesday, Dec. 28 2021
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-021-00740-y
Development of ACE2 autoantibodies after SARS-CoV-2 infection - PMC
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8415618/
I-RECOVER Protocol - FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/covid-19-protocols/i-recover-protocol/
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Spike Protein from Infection or Vaccine Can Be Problematic for Some (An Article Review)
Spike Protein from Infection or Vaccine Can Be Problematic for Some (An Article Review)
Researchers from UC Davis and Harvard have written an article published in NEJM about the role of anti-idiotype antibodies possibly causing autoimmune disease in some individuals. They think that the network hypothesis formulated by Neil K Jerne (a Nobel Laureate) maybe at play. Let's review.
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Reference List from Monday, Dec. 27 2021
Antibodies mimicking the virus may explain long haul COVID-19, rare vaccine side effects
https://health.ucdavis.edu/newsroom/news/headlines/antibodies-mimicking-the-virus-may-explain-long-haul-covid-19-rare-vaccine-side-effects/2021/11
A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMcibr2113694
Niels K. Jerne - Facts
https://www.nobelprize.org/prizes/medicine/1984/jerne/facts/
Niels Jerne - Explaining the Human Immune System - SciHi BlogSciHi Blog
http://scihi.org/niels-jerne-immune-system/
Niels K. Jerne - Nobel Lecture: The Generative Grammar of the Immune System - NobelPrize.org
https://www.nobelprize.org/prizes/medicine/1984/jerne/lecture/
César Milstein - Nobel Lecture: From the Structure of Antibodies to the Diversification of the Immune Response
https://www.nobelprize.org/prizes/medicine/1984/milstein/lecture/
Epitope Selection - immunoGlobe GmbH - Your Antibody Manufacturer & Service Provider
https://www.immunoglobe.com/epitope-selection.html
Epitope - Wikipedia
https://en.wikipedia.org/wiki/Epitope
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Bacillus Anthracis | Properties, Pathology, Disease, Management Approach
Bacillus Anthracis | Properties, Pathology, Disease, Management Approach
Bacillus anthracis is a gram-positive, rod-shaped bacteria. It causes anthrax that can be deadly in many cases. It is found naturally in soil & competing to get access to nutrients, which it produces by breaking down other organisms. The disease spreads when the bacteria are inhaled, ingested, or by contact on a skin wound. Let’s review its properties, pathogenesis, toxins, disease types, and the management approach.
00:00 Introduction
00:26 Properties
00:53 Genetic material
01:06 Incubation time
01:22 Diseases
01:32 Transmission and lifecycle
02:19 Route of entry
02:37 Virulence factors
03:19 Spores
04:32 Pathogenesis
07:52 Diseases
09:26 Management approach
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Book reference:
Papadakis, Maxine A.; McPhee, Stephen J.; Rabow, Michael W..
CURRENT Medical Diagnosis and Treatment 2016 (LANGE CURRENT Series) .
McGraw-Hill Education. Kindle Edition.
More references
https://www.nejm.org/doi/full/10.1056/nejm199909093411107
https://en.wikipedia.org/wiki/Bacillus_anthracis
https://en.wikipedia.org/wiki/Anthrax_toxin
https://en.wikipedia.org/wiki/2001_anthrax_attacks
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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UK Common Cold Maybe Omicron, South Africa - Peak is Over
UK Common Cold Maybe Omicron, South Africa - Peak is Over
It seems that South Africa's peak is over. Zoe app reports that half of the cases of the common cold is Omicron. Let's review the data.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References for Friday, Dec. 24 2021 Talk
LATEST CONFIRMED CASES OF COVID-19 IN SOUTH AFRICA (23 December 2021) - NICD
https://www.nicd.ac.za/latest-confirmed-cases-of-covid-19-in-south-africa-23-december-2021/
News24 Covid-19 Dashboard | Gauteng
https://covid-19dashboard.news24.com/gauteng
Wards Cases Public (2021)
https://gis.nicd.ac.za/portal/apps/opsdashboard/index.html#/6564559bcf32429ca29ccbd290d094dd
Coronavirus COVID-19 (2019-nCoV)
https://www.arcgis.com/apps/dashboards/bda7594740fd40299423467b48e9ecf6
South Africa: Coronavirus Pandemic Country Profile - Our World in Data
https://ourworldindata.org/coronavirus/country/south-africa
South Africa: Coronavirus Pandemic Country Profile - Our World in Data
https://ourworldindata.org/coronavirus/country/south-africa
South Africa: Coronavirus Pandemic Country Profile - Our World in Data
https://ourworldindata.org/coronavirus/country/south-africa
South Africa COVID - Coronavirus Statistics - Worldometer
https://www.worldometers.info/coronavirus/country/south-africa/
Update On Covid-19 (Thursday 23 December 2021) - SA Corona Virus Online Portal
https://sacoronavirus.co.za/2021/12/23/update-on-covid-19-thursday-23-december-2021/
Early assessment of the clinical severity of the SARS-CoV-2 Omicron variant in South Africa | medRxiv
https://www.medrxiv.org/content/10.1101/2021.12.21.21268116v1
South African and UK hospitalisation data: what it tells us about how deadly omicron is
https://theconversation.com/south-african-and-uk-hospitalisation-data-what-it-tells-us-about-how-deadly-omicron-is-174178
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Omicron - Good News Continues (60% Less Risk of Hospitalization by Omicron)
Omicron - Good News Continues (60% Less Risk of Hospitalization by Omicron as Compared to Delta - Studies roundup)
Let's review the latest studies about the risk of hospitalization, the severity of the disease, and the risk in previously infected, vaccinated vs. unvaccinated.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References Thursday, Dec. 23 2021 16:37 PM
HKUMed finds Omicron SARS-CoV-2 can infect faster and better than Delta in human bronchus but with less severe infection in lung - News | HKUMed
https://www.med.hku.hk/en/news/press/20211215-omicron-sars-cov-2-infection
Severity of Omicron variant of concern and vaccine effectiveness against symptomatic disease: national cohort with nested test negative design study in Scotland — University of Edinburgh Research Explorer
https://www.research.ed.ac.uk/en/publications/severity-of-omicron-variant-of-concern-and-vaccine-effectiveness-
Early assessment of the clinical severity of the SARS-CoV-2 Omicron variant in South Africa | medRxiv
https://www.medrxiv.org/content/10.1101/2021.12.21.21268116v1
Early assessment of the clinical severity of the SARS-CoV-2 Omicron variant in South Africa
https://www.medrxiv.org/content/10.1101/2021.12.21.21268116v1.full.pdf
Report 49 - Growth, population distribution and immune escape of Omicron in England | Faculty of Medicine | Imperial College London
https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-49-Omicron/
Report 50 - Hospitalisation risk for Omicron cases in England | Faculty of Medicine | Imperial College London
https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-50-severity-omicron/
2021-12-22-COVID19-Report-50.pdf
https://www.imperial.ac.uk/media/imperial-college/medicine/mrc-gida/2021-12-22-COVID19-Report-50.pdf
omicron spike protein less efficient gupta labs - Google Search
https://www.google.com/search?q=omicron+spike+protein+less+efficient+gupta+labs&ei=kAfFYf-vH8nVtAbCvZHgBA&ved=0ahUKEwj_t7P1ivv0AhXJKs0KHcJeBEwQ4dUDCA4&uact=5&oq=omicron+spike+protein+less+efficient+gupta+labs&gs_lcp=Cgdnd3Mtd2l6EAM6BwgAEEcQsAM6BQghEKABOgUIIRCrAkoECEEYAEoECEYYAFDYBVjuFmDpF2gBcAJ4AIABhgGIAY8IkgEDOC4zmAEAoAEByAEIwAEB&sclient=gws-wiz
Omicron Spike Protein is Less Efficient - Random COVID Questions with Dr. Been (#162) - YouTube
https://www.youtube.com/watch?v=Y7LNN0KF_Uk&ab_channel=DrbeenMedicalLectures
(22) Gupta Lab on Twitter: "Sharing some potentially significant findings relating to Omicron given the current situation. First of all huge thanks to the team working flat out- Bo Meng, @isabella_atmf and to our collaborators both in G2P, J2P along with @SystemsVirology. Findings as follows:" / Twitter
https://twitter.com/guptar_lab/status/1471941645797146628?s=21
Bounding the levels of transmissibility & immune evasion of the Omicron variant in South Africa | medRxiv
https://www.medrxiv.org/content/10.1101/2021.12.19.21268038v1
Bounding the levels of transmissibility & immune evasion of the Omicron variant in South Africa
https://www.medrxiv.org/content/10.1101/2021.12.19.21268038v1.full.pdf
Breakthrough infections generate ‘super immunity’ to COVID-19, study suggests | OHSU News
https://news.ohsu.edu/2021/12/16/breakthrough-infections-generate-super-immunity-to-covid-19-study-suggests
Antibody Response and Variant Cross-Neutralization After SARS-CoV-2 Breakthrough Infection | Infectious Diseases | JAMA | JAMA Network
https://jamanetwork.com/journals/jama/fullarticle/2787447
Pfizer and BioNTech Provide Update on Omicron Variant | Pfizer
https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-provide-update-omicron-variant
Moderna - Moderna Announces Preliminary Booster Data and Updates Strategy to Address Omicron Variant
https://investors.modernatx.com/news/news-details/2021/Moderna-Announces-Preliminary-Booster-Data-and-Updates-Strategy-to-Address-Omicron-Variant/default.aspx
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Omicron - Moderna Booster Seems to Be Protective
Omicron - Moderna Booster Seems to Be Protective
Yesterday ( Dec 20th 2021) Moderna announced the results of their booster efficacy in generating neutralizing antibodies. Let's review their data and the process of testing boosters.
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References
https://investors.modernatx.com/news/news-details/2021/Moderna-Announces-Preliminary-Booster-Data-and-Updates-Strategy-to-Address-Omicron-Variant/default.aspx
https://clinicaltrials.gov/ct2/show/NCT04927065
https://www.nature.com/articles/s41591-021-01527-y
https://en.wikipedia.org/wiki/SARS-CoV-2_Beta_variant
https://clinicaltrials.gov/ct2/show/NCT04927065
https://www.modernatx.com/mrna-1273213
https://www.cancertherapyadvisor.com/home/general-medicine/moderna-to-test-covid-19-booster-candidates-against-omicron-variant/
https://clinicaltrials.gov/ct2/show/NCT04927065
https://www.newscientist.com/article/2237475-covid-19-news-who-calls-for-holiday-festivities-to-be-postponed/
https://www.fda.gov/media/144637/download

https://www.usatoday.com/story/news/nation/2021/12/20/moderna-booster-effective-against-omicron-study-shows-covid-19-news/8963500002/
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Simultaneous Reinfection and Breakthrough Case Report
Simultaneous Reinfection and Breakthrough Case Report
A young female suffered reinfection and a breakthrough simultaneously. Let's review her case history.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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(12/20/2021) COVID Readiness For Christmas
(12/20/2021) COVID Readiness For Christmas
Let's discuss the available options before and after the possible exposure to SARS-COV-2 during this holiday season.
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References:
Tests that are expected to fail: https://www.fda.gov/medical-devices/coronavirus-covid-19-and-medical-devices/sars-cov-2-viral-mutations-impact-covid-19-tests
Before the exposure: general measures. Healthy state of immune system.
Correct vitamin D levels: https://pubmed.ncbi.nlm.nih.gov/33512007/
Forest bathing: https://www.researchgate.net/publication/5458955_A_forest_bathing_trip_increases_human_natural_killer_activity_and_expression_of_anti-cancer_proteins_in_female_subjects
Some monoclonal antibodies aren't as effective against Omicron
https://www.pbs.org/newshour/health/omicron-may-sideline-two-leading-drugs-against-covid-19
GlaxoSmithKlein: https://www.sotrovimab.com/?cc=ps_4FYVU9R0NX1040193&mcm=300000&gclid=Cj0KCQiA8ICOBhDmARIsAEGI6o0w-vDVdeUBSFWDYQtjxTANHe_ydQ7dY5u-GCvJomGxaYNaRmT5jksaAvzSEALw_wcB&gclsrc=aw.ds
Pfizer's Paxlovid: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-announces-additional-phase-23-study-results
EMA advice for Paxlovid: https://www.pfizer.com/news/press-release/press-release-detail/ema-issues-advice-potential-early-use-pfizers-novel-covid
Merck's Molnupiravir: https://www.merck.com/news/merck-and-ridgeback-statement-on-positive-fda-advisory-committee-vote-for-investigational-oral-antiviral-molnupiravir-for-treatment-of-mild-to-moderate-covid-19-in-high-risk-adults/
EMA advice for Molnupiravir: https://www.ema.europa.eu/en/news/ema-issues-advice-use-lagevrio-molnupiravir-treatment-covid-19
Monoclonal Antibodies:
Bamlanivimab: https://www.covid19.lilly.com/bam-ete
Regeneron: https://www.regeneron.com/about/perspectives/immunocompromised-covid-treatment
https://www.regeneron.com/medicines/casirivimab-imdevimab
AstraZeneca: https://www.astrazeneca.com/media-centre/press-releases/2021/evusheld-long-acting-antibody-combination-authorised-for-emergency-use-in-the-us-for-pre-exposure-prophylaxis-prevention-of-covid-19.html
Article: https://www.medicalnewstoday.com/articles/pfizer-oral-antiviral-safe-and-effective-against-sars-cov-2
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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5 Mechanisms of ADE (How Does Antibody Dependent Enhancement Occur?)
5 Mechanisms of ADE (How Does Antibody-Dependent Enhancement Occur?)
How Does ADE Work?
Please read and agree to the disclaimer before watching this video.
Coronavirus
More lectures on drbeen.com
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In today’s discussion we will go over the antibody dependent enhancement mechanisms, and will figure out if the coronavirus is affected by this mechanism.
Special comment by Dr. Mobeen about the possibility of cytokine and its solution in light of the ADE concepts.
A good article to go over
https://www.sciencedirect.com/science/article/pii/S1201971220307311
#drbeen #koolbeens #COVID ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
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Higher Risk of Heart Problems From Moderna Compared to COVID in Under 40
Higher Risk of Heart Problems From Moderna Compared to COVID in Under 40
A large study (38 million individuals from UK) assessed the heart problems in the vaccinated vs., from COVID. Moderna's vaccine for under 40 caused more myocarditis after the second dose compared to the COVID. Similarly Oxford/AstraZeneca's vaccine caused more heart problems in women. Overall the data showed that COVID causes more heart problems compared to vaccines.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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(Dec 18, 2021) Omicron UK Symptoms
(Dec 18, 2021) Omicron UK Symptoms
Let's review the symtpoms reported to confirmed COVID patients (outpatinet) to ZOE app.
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ZOE app link: https://covid.joinzoe.com/post/omicron-and-cold-like-symptoms-rapidly-taking-over-in-london
https://ourworldindata.org/coronavirus/country/united-kingdom
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Random COVID Questions with Dr. Been (#163)
Random COVID Questions with Dr. Been (#163)
Let's have fun and talk :-)
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Disclaimer:
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Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Omicron Spike Protein is Less Efficient - Random COVID Questions with Dr. Been (#162)
Random COVID Questions with Dr. Been (#162)
Let's have fun and talk :-)
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Disclaimer:
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3
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Europe Pre-Omicron, How are Vaccines Working? (A Talk With Paul Bork - 12/17/2021)
Europe Pre-Omicron, How are Vaccines Working? (A Talk With Paul Bork - 12/17/2021)
Vaccine and Europe has been a long overdue discussion. Omicron had us focus on the new situation for a few days. I wanted to have a quick look at Europe so that we can level set where Europe is before Omicron spreads more. Let's review this data with our KoolBeen Paul Bork.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
2
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Vaccines in 5-11 Years Caused 8 Cases of Heart Problems - CDC Announces (Dec 16 2021)
Vaccines in 5-11 Years Caused 8 Cases of Heart Problems - CDC Announces (Dec 16 2021)
CDC said today (Thursday December 16th 2021) that eight children had cardiac inflammation from Pfizer vaccines. Let's review the news.
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References
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/myocarditis.html
https://www.reuters.com/world/us/eight-heart-inflammation-cases-seen-among-young-kids-who-got-covid-19-shot-us-2021-12-16/
https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-11-2-3/03-COVID-Jefferson-508.pdf
https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-11-2-3/07-COVID-Woodworth-508.pdf
FDA Projections: https://www.fda.gov/media/153447/download
DrBeen presentation of the FDA approval and stats.
https://youtu.be/HHEGOXG-wY8
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
8
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Omicron - 70 Times More Infectious Than Delta and Significantly Less Severe (Study from HKUMed)
Omicron - 70 Times More Infectious Than Delta and Significantly Less Severe (Study from HKUMed)
Why is Omicron more transmissible and less severe? An ex-vivo study (yet in peer-review) has demonstrated for the first time an insight into the potential mechanism. Let's review.
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References
https://www.drbeen.com/
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7973348/#:~:text=The%20median%20tissue%20culture%20infectious,of%20a%20given%20cell%20culture.
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/ex-vivo
https://www.med.hku.hk/en/news/press/20211215-omicron-sars-cov-2-infection
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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(Dec 15, 2021) Omicron - Prof. Dr. Terrence Kommal Shares South Africa Cases and Hospitalizations
(Dec 15, 2021) Omicron - Prof. Dr. Terrence Kommal Shares South Africa Cases and Hospitalizations
News is circulating of the preprint in-vitro study demonstrating immune escape. Let's review this study, and also get the latest stats on South Africa with Dr. Kommal.
Prof. Dr. Kommal is a star on South Africa's development and progress. Let's review the Omicron and COVID-19 situation in South Africa with him.
Prof. Kommal's brief bio:
Prof. Kommal had been selected as a Young Global Leader of the World Economic Forum. In March 2021, he had been selected as one of 112 YGL’s in the world for 2021.
Prof Terrence Kommal is a medical doctor in South Africa. He has a proven history of achievement and he excels as a servant leader dedicated to sustainable and impact-focussed organisations. He is the founder of the Medical Experts Consulting Group. The company and its entities provided services to the SA govt for medical work and claims worth more than R2 billon per annum.
He has previously served in a range of senior roles in South Africa in govt and private sector. He is currently the CEO of the Omdutt Group, a group that actively invests and manages sustainable businesses in healthcare and other sectors in South Africa, Mauritius and the UAE.
He is a former technical expert on South Africa’s B4SA-COVID 19 workstream.
In recognition on Prof Kommal’s remarkable contributions and leadership in healthcare, North West University in 2020 has appointed him as their first Extraordinary Professor of Practice. Now in December 2021, he has been honoured and invited to speak on behalf of the almost 30 000 graduates and alumni of University of Stellenbosch’s Business School.
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More lectures at drbeen.com
Link to the study: https://krisp.org.za/manuscripts/MEDRXIV-2021-267417v1-Sigal.pdf
https://covid-19dashboard.news24.com/gauteng
https://www.theguardian.com/world/2021/dec/03/omicron-covid-variant-record-rate-of-infection-south-africa-gauteng
https://ourworldindata.org/coronavirus/country/south-africa
https://ourworldindata.org/coronavirus/country/south-africa
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Omicron Reduces Vaccine Efficacy - Oxford Study (Preprint)
Omicron Reduces Vaccine Efficacy - Oxford Study (Preprint)
A small preprint study from Oxford University demonstrates that Omicron escapes vaccines; in some cases 100%. Let's review the study.
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References
https://www.medrxiv.org/content/10.1101/2021.12.10.21267534v1
https://www.medrxiv.org/content/10.1101/2021.12.10.21267534v1.full.pdf
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Disclaimer:
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Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Dr. Keith Berkowitz Discusses Long COVID and More
Dr. Keith Berkowitz Discusses Long COVID and More
Keith Wayne Berkowitz, M.D., is the Founder and Medical Director of the Center for Balanced Health. He combines expertise in both traditional and complementary medicine. Prior to starting the Center for Balanced Health, he was the Medical Director and Business Director of The Atkins Center for Complementary Medicine. He was an associate of Dr. Robert C. Atkins since 1999.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
59
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