Low Dose Naltrexone (LDN) - Mechanism of Action
Low Dose Naltrexone (LDN) - Mechanism of Action
LDN is used for chronic diseases, multiple sclerosis, autoimmune thyroid disease, and various cancers. Let's review its mechanism of action.
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Wednesday, Feb. 2 2022
Naltrexone | Naltrexone - Bupropion Combination - Mechanism of Action
https://psychscenehub.com/psychinsights/naltrexone-naltrexone-bupropion-combination-mechanism-of-action-psychopharmacology-and-clinical-application-2/
IL-6 in Inflammation, Immunity, and Disease - PMC
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4176007/
Ventral tegmental area - Wikipedia
https://en.wikipedia.org/wiki/Ventral_tegmental_area
Mesolimbic pathway - Wikipedia
https://en.wikipedia.org/wiki/Mesolimbic_pathway
Striatum - Wikipedia
https://en.wikipedia.org/wiki/Striatum#Structure
Frontiers | Naltrexone Inhibits IL-6 and TNFα Production in Human Immune Cell Subsets following Stimulation with Ligands for Intracellular Toll-Like Receptors | Immunology
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00809/full
366
views
Sharing is Caring
Sharing is Caring
Interesting times. Let's discuss today's day.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
9
views
Long COVID Discussion with Dr. Bruce Patterson
Long COVID Discussion with Dr. Bruce Patterson
Dr. Bruce Patterson’s team has discovered that the S1 pieces of the spike proteins persist in the monocytes resulting in immune dysregulation and long-haul syndrome. Let’s discuss these findings with him.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
Disclosure:
Dr. Mobeen Syed, or DrBeen have no commercial interest with Dr. Bruce Patterson’s organization.
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
#drbeen #koolbeens #COVID
References:
Science Magazine Article
https://www.science.org/content/article/rare-cases-coronavirus-vaccines-may-cause-long-covid-symptoms
Dr. Patterson's team's papers:
https://www.frontiersin.org/articles/10.3389/fimmu.2021.700782/full
https://www.frontiersin.org/articles/10.3389/fimmu.2021.746021/full
161
views
CDC Quarantine Guidance for Unvaccinated and Vaccinated (Jan 28th 2022)
NeoCov (Jan 28th 2022)
There are some headlines about NeoCov and a preprint about it. Let's see if this is a concern.
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
https://www.biorxiv.org/content/10.1101/2022.01.24.477490v1
https://www.cdc.gov/media/releases/2021/s1227-isolation-quarantine-guidance.html
12
views
All About NeoCov | A Doctor Explains
NeoCov (Jan 28th 2022)
There are some headlines about NeoCov and a preprint about it. Let's see if this is a concern.
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
https://www.biorxiv.org/content/10.1101/2022.01.24.477490v1
https://www.cdc.gov/media/releases/2021/s1227-isolation-quarantine-guidance.html
150
views
Weekly COVID Stats with Paul Bork (Jan 28th 2022)
Weekly COVID Stats with Paul Bork (Jan 28th 2022)
Let's review Omicron and COVID stats with Paul Bork. Paul is a #koolbeen with the title EndBeen as he is looking forward to the end of the pandemic.
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
8
views
Another Good Study | Fascinating Questions with Dr. Been (#178)
Another Fascinating Study, and Random Questions with Dr. Been (#178)
Let's have fun and talk :-)
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Thursday, Jan. 27 2022
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection | Nature Communications
https://www.nature.com/articles/s41467-021-22036-z
Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques | bioRxiv
https://www.biorxiv.org/content/10.1101/2021.04.02.438262v1
Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2 | Nature
https://www.nature.com/articles/s41586-021-04388-0
22
views
Safe Without Getting COVID | T Cell Memory Without Detectable Infection
T Cell Memory Without Detectable Infection
This interesting study demonstrates that the household contacts of the COVID patients develop T cell memory to SARS-COV-2 despite testing negative. Let's review.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Thursday, Jan. 27 2022
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection | Nature Communications
https://www.nature.com/articles/s41467-021-22036-z
Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques | bioRxiv
https://www.biorxiv.org/content/10.1101/2021.04.02.438262v1
Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2 | Nature
https://www.nature.com/articles/s41586-021-04388-0
73
views
Unvaccinated - Death Rate by Age
Unvaccinated - Death Rate by Age (Encouraging Data)
Ourworld in data has death rate by vaccination status and age charts. Let's review these.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Tuesday, Jan. 25 2022
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
Switzerland: COVID-19 weekly death rate by vaccination status, All ages
https://ourworldindata.org/grapher/switzerland-covid-19-weekly-death-rate-by-vaccination-status?country=~All+ages
How do death rates from COVID-19 differ between people who are vaccinated and those who are not? - Our World in Data
https://ourworldindata.org/covid-deaths-by-vaccination
Switzerland: COVID-19 weekly death rate by vaccination status, All ages
https://ourworldindata.org/grapher/switzerland-covid-19-weekly-death-rate-by-vaccination-status?country=~All+ages
45
views
FDA Fast Track Application for Tempol - A Potential At Home COVID Therapy
FDA Fast Track Application for Tempol - A Potential At Home COVID Therapy
Recently, researchers from theNational Institutes of Health(NIH) highlighted Tempol as a potential home antiviral treatment for COVID-19 (https://covid19.nih.gov/news-and-stories/tempol-potential-home-treatment-covid-19). Let's review the mechanism of this drug.
URL list from Wednesday, Jan. 26 2022
Adamis Pharmaceuticals Announces a Publication with the Human Immune Monitoring Center at Stanford Demonstrating Tempol Significantly Inhibited Multiple Cytokines from COVID-19 Patient’s Cells | Adamis Pharmaceuticals Corporation
https://ir.adamispharmaceuticals.com/news-releases/news-release-details/adamis-pharmaceuticals-announces-publication-human-immune
TEMPOL: A Potential Home Treatment for COVID-19 | NIH COVID-19 Research
https://covid19.nih.gov/news-and-stories/tempol-potential-home-treatment-covid-19
Brief report: Tempol, a novel antioxidant, inhibits both activated T cell and antigen presenting cell derived cytokines in-vitro from COVID-19 patients - PMC
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8378988/
Study to Evaluate the Effects of Tempol (MBM-02) in COVID-19 Patients. - Full Text View - ClinicalTrials.gov
https://clinicaltrials.gov/ct2/show/NCT04729595
Peripheral blood mononuclear cell - Wikipedia
https://en.wikipedia.org/wiki/Peripheral_blood_mononuclear_cell#:~:text=A%20peripheral%20blood%20mononuclear%20cell,)%20have%20multi%2Dlobed%20nuclei.
Interleukin 1 beta - Wikipedia
https://en.wikipedia.org/wiki/Interleukin_1_beta
Granulocyte-macrophage colony-stimulating factor - Wikipedia
https://en.wikipedia.org/wiki/Granulocyte-macrophage_colony-stimulating_factor
CCL20 - Wikipedia
https://en.wikipedia.org/wiki/CCL20
Interleukin 10 - Wikipedia
https://en.wikipedia.org/wiki/Interleukin_10
Interleukin 2 - Wikipedia
https://en.wikipedia.org/wiki/Interleukin_2#:~:text=Interleukin%2D2%20(IL%2D2,that%20are%20responsible%20for%20immunity.
Interleukin 6 - Wikipedia
https://en.wikipedia.org/wiki/Interleukin_6
Interleukin 21 - Wikipedia
https://en.wikipedia.org/wiki/Interleukin_21
13
views
Neuromodulation for Long COVID, Death Rate by Vaccine Status (Switzerland, US, England, Chile)
Neuromodulation for Long COVID and The Death Rate by Vaccination Status (Switzerland, US, England, Chile)
Our world in data has death rate by vaccination status charts. Let's review these. Plus neuromodulation for Long COVID.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Tuesday, Jan. 25 2022 18:41 PM
To copy this list, type [Ctrl] A, then type [Ctrl] C.
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
Long-COVID symptoms improved with neuromodulation
https://www.europeanpharmaceuticalreview.com/news/158262/long-covid-symptoms-improved-with-neuromodulation/
Switzerland: COVID-19 weekly death rate by vaccination status, All ages
https://ourworldindata.org/grapher/switzerland-covid-19-weekly-death-rate-by-vaccination-status?country=~All+ages
How do death rates from COVID-19 differ between people who are vaccinated and those who are not? - Our World in Data
https://ourworldindata.org/covid-deaths-by-vaccination
Switzerland: COVID-19 weekly death rate by vaccination status, All ages
https://ourworldindata.org/grapher/switzerland-covid-19-weekly-death-rate-by-vaccination-status?country=~All+ages
46
views
Vaccines, Boosters, Previous Infections and Omicron - Data from UK
Vaccines, Boosters, Previous Infections and Omicron - Data from UK
Let's review the data presented in the technical brief number 34 from UK health security agency.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Tuesday, Jan. 25 2022
SARS-CoV-2 variants of concern and variants under investigation- Technical briefing 34
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1048395/technical-briefing-34-14-january-2022.pdf
No Omicron immunity without booster, study finds – Harvard Gazette
https://news.harvard.edu/gazette/story/2022/01/no-omicron-immunity-without-booster-study-finds/#:~:text=Researchers%20found%20that%20traditional%20dosing,and%20neutralizing%20the%20Omicron%20variant.
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant: Cell
https://www.cell.com/cell/fulltext/S0092-8674(21)01496-3#%20
How long does a COVID booster shot offer protection against omicron? : Goats and Soda : NPR
https://www.npr.org/sections/goatsandsoda/2022/01/19/1071809356/covid-booster-omicron-efficacy
Effectiveness of BNT162b2 Vaccine against Omicron Variant in South Africa | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMc2119270
Pfizer and BioNTech Publish Data from Two Laboratory Studies on COVID-19 Vaccine-induced Antibodies Ability to Neutralize SARS-CoV-2 Omicron Variant | Pfizer
https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-publish-data-two-laboratory-studies
Omicron's Incubation Period Is Short: Here's Why That Matters
https://www.yahoo.com/lifestyle/omicrons-incubation-period-short-heres-185700330.html
Pfizer and BioNTech launch study of omicron vaccine, and FDA halts use of two COVID antibody treatments
https://finance.yahoo.com/m/b8fd05e1-7023-3b79-ad21-c01bef528216/pfizer-and-biontech-launch.html
Fauci says 'prudent' to have Omicron vaccine, but may not be needed
https://www.yahoo.com/news/fauci-says-prudent-omicron-vaccine-160302816.html
36
views
Coronavirus Immunity 18 Years After The Infection
Coronavirus Cross Immunity 18 Years After Infection with SARS-COV-1
This small but important study shows that SARS-COV-1 infection created memory cells that are activated after 18 years.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Reference: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2788474/
URL list from Monday, Jan. 24 2022
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
The durability of immunity against reinfection by SARS-CoV-2: a comparative evolutionary study - The Lancet Microbe
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(21)00219-6/fulltext
Duration of Antibody Responses after Severe Acute Respiratory Syndrome - PMC
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2851497/
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls | Nature
https://www.nature.com/articles/s41586-020-2550-z
T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV - PMC
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7113894/
25
views
Natural Immunity Is Powerful - Finally A CDC Study
Finally CDC Understands The Protection by COVID Infection
A large study of COVID patients from California and New York shows robust and superior protection from COVID infection compared to vaccines. However, of course, it is a huge risk as well to be infected so it is not recommended.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Monday, Jan. 24 2022 16:22 PM
To copy this list, type [Ctrl] A, then type [Ctrl] C.
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
COVID-19 Cases and Hospitalizations by COVID-19 Vaccination Status and Previous COVID-19 Diagnosis — California and New York, May–November 2021 | MMWR
https://www.cdc.gov/mmwr/volumes/71/wr/mm7104e1.htm#T1_down
COVID-19 Cases and Hospitalizations by COVID-19 Vaccination Status and Previous COVID-19 Diagnosis — California and New York, May–November 2021
https://stacks.cdc.gov/view/cdc/113253
COVID-19 Cases and Hospitalizations by COVID-19 Vaccination Status and Previous COVID-19 Diagnosis — California and New York, May–November 2021
https://www.cdc.gov/mmwr/volumes/71/wr/pdfs/mm7104e1-H.pdf
17
views
CDC Director - Get Boosters to Be Up to Date
CDC Director Get Boosters to Be Up to Date
On 5th January Administration said that they have no plans to change the definition of "fully vaccinated". Now, CDC just pivoted the language ...
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Saturday, Jan. 22 2022
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
White House: No plans to change definition of 'fully vaccinated' | TheHill
https://thehill.com/policy/healthcare/588356-white-house-no-plans-to-change-definition-of-fully-vaccinated
(25) Robby Starbuck on Twitter: "Another CDC switcharoo! The CDC Dir. Rochelle Walensky just announced that you’re not fully vaccinated unless you’ve had your booster and now they won’t say fully vaccinated anymore — they’ll say "up to date". Sounds like they expect a LOT more shots just like we predicted! https://t.co/Sn0Ktg3hw5" / Twitter
https://twitter.com/robbystarbuck/status/1484602323959791620
CDC director turns to media consultant as Covid-19 messaging frustrations mount - CNNPolitics
https://www.cnn.com/2022/01/07/politics/rochelle-walensky-cdc-communications-covid-19/index.html
26
views
Omicron BA.2 Variant
Omicron BA.2 Variant
BA.2 sub-lineage is in the news because of its increasing frequency compared to BA.1. Let's review the following questions:
What is it?
What are the mutations?
Is it more transmissible?
Is it more lethal?
Will it provide cross-reactivity?
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Saturday, Jan. 22 2022
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
SARS-CoV-2 Omicron variant - Wikipedia
https://en.wikipedia.org/wiki/SARS-CoV-2_Omicron_variant
Scientists find ‘stealth’ version of Omicron that may be harder to track | Coronavirus | The Guardian
https://www.theguardian.com/world/2021/dec/07/scientists-find-stealth-version-of-omicron-not-identifiable-with-pcr-test-covid-variant
Denmark to shut down public venues as virus infections rise | AP News
https://apnews.com/article/coronavirus-pandemic-lifestyle-health-travel-art-galleries-58f88e5635dc80fa56ad3a95343d904c
Denmark: Coronavirus Pandemic Country Profile - Our World in Data
https://ourworldindata.org/coronavirus/country/denmark
Sequence of traveller from South Africa failed to get assigned to any lineage by pangolin, with a long branch to Omicron · Issue #359 · cov-lineages/pango-designation
https://github.com/cov-lineages/pango-designation/issues/359
Proposal to split B.1.1.529 to incorporate a newly characterised sibling lineage · Issue #361 · cov-lineages/pango-designation
https://github.com/cov-lineages/pango-designation/issues/361
Thread by @PeacockFlu on Thread Reader App – Thread Reader App
https://threadreaderapp.com/thread/1483768659420094464.html
(17) shay fleishon on Twitter: "I took the defining mutations of BA.1 & BA.2 (NS only), and compared the resemblance between the 2 variants in main parts of the genome. Some difference in S1. E is the same, N & M are different in 1 mutation between the two variants. And...quite a difference when we go to ORF1ab https://t.co/xjl1IRvhmM" / Twitter
https://twitter.com/shay_fleishon/status/1480934070012059649?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1480934070012059649%7Ctwgr%5E%7Ctwcon%5Es1_&ref_url=https%3A%2F%2Fthreadreaderapp.com%2Fthread%2F1483768659420094464.html
(18) Bloom Lab on Twitter: "Here are site-wise plots generated from https://t.co/dr4oGVHUrS that explain why. BA.2 less antigenic escape than BA.1 because it lacks G446S. BA.1 + R346K is more escape because site 346 is major antigenic site. (7/n) https://t.co/bm8ZEN0Ty2" / Twitter
https://twitter.com/jbloom_lab/status/1470442877494824961?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1470442877494824961%7Ctwgr%5E%7Ctwcon%5Es1_&ref_url=https%3A%2F%2Fthreadreaderapp.com%2Fthread%2F1483768659420094464.html
(18) Bloom Lab on Twitter: "Here are site-wise plots generated from https://t.co/dr4oGVHUrS that explain why. BA.2 less antigenic escape than BA.1 because it lacks G446S. BA.1 + R346K is more escape because site 346 is major antigenic site. (7/n) https://t.co/bm8ZEN0Ty2" / Twitter
https://twitter.com/jbloom_lab/status/1470442877494824961?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1470442877494824961%7Ctwgr%5E%7Ctwcon%5Es1_&ref_url=https%3A%2F%2Fthreadreaderapp.com%2Fthread%2F1483768659420094464.html
(25) Mike Honey 💉💉💉 on Twitter: "@PeacockFlu Thanks for such a thorough explainer. Here’s the latest frequency picture for BA.2 https://t.co/3ADwoOPrh4" / Twitter
https://twitter.com/mike_honey_/status/1484855167275376645?s=21
Overview | Sites in SARS-CoV-2 RBD where mutations escape antibody binding
https://jbloomlab.github.io/SARS2_RBD_Ab_escape_maps/escape-calc/
(25) Chise 🧬🧫🦠💉 on Twitter: "Guys, BA.2 isn’t new. It’s been around since last year. It’s a sub-lineage to BA.1. They’re both still Omicron. It isn’t expected to be any more severe or expected to cause another wave. It might just eventually replace BA.1. End of the day, still Omicron. Let’s not lose focus." / Twitter
https://twitter.com/sailorrooscout/status/1484507422513319941?s=21
GISAID - hCov19 Variants
https://www.gisaid.org/hcov19-variants/
Nextstrain / ncov / gisaid / global
https://nextstrain.org/ncov/gisaid/global?tl=country
38
views
(Jan 21st, 2022) My COVID Status
(Jan 21st, 2022) My COVID Status
Today's status. Hopefully last day of the status as I feel much better even without meds.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
7
views
Why Fewer N-Antigen Antibodies in Double Dose Vaccinated?
Why Fewer N-Antigen Antibodies in Double Dose Vaccinated?
Someone sent the Vaccine Surveillence report for the week 42 issued by UK Health Security Agency. It states that there are fewer N-Antibodies after two dose vaccination. Let's review the mechanism.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Jan. 21 2022
COVID-19 vaccine surveillance report - week 42
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1027511/Vaccine-surveillance-report-week-42.pdf
Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure | mSystems
https://journals.asm.org/doi/10.1128/mSystems.00095-21
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA | Nature Communications
https://www.nature.com/articles/s41467-021-21953-3
Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 | Acta Pharmacologica Sinica
https://www.nature.com/articles/s41401-020-0485-4
Not just antibodies: B cells and T cells mediate immunity to COVID-19 | Nature Reviews Immunology
https://www.nature.com/articles/s41577-020-00436-4
15
views
(Jan 20th, 2022) My COVID Status
(Jan 20th, 2022) My COVID Status
Today's status.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
9
views
Weekly COVID Stats with Paul Bork (Jan 20th 2022)
Weekly COVID Stats with Paul Bork (Jan 20th 2022)
Let's review Omicron and COVID stats with Paul Bork. Paul is a #koolbeen with the title EndBeen as he is looking forward to the end of the pandemic.
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
7
views
(Jan 19th, 2022) My COVID Status
(Jan 19th, 2022) My COVID Status
Today's status.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
8
views
Omicron in Washington State
Omicron in Washington State
Washington State has a great document about variants and their sequences. In this document they also have symptom variations from delta. Let's review.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Wednesday, Jan. 19 2022
SARS-CoV-2 Sequencing and Variants in Washington State
https://www.doh.wa.gov/Portals/1/Documents/1600/coronavirus/data-tables/420-316-SequencingAndVariantsReport.pdf
5
views
Omicron Headache and Jaw Pain
Omicron Headache and Jaw Pain
Headaches and Jaw Pains are frequent and one of the most common symptoms of Omicron COVID. Let's review the causes and possible management.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Wednesday, Jan. 19 2022
Why Exactly Omicron Causes Headaches, and What You Need to Know About Treating Them
https://www.yahoo.com/lifestyle/why-exactly-omicron-causes-headaches-151600786.html
Covid-19: Runny nose, headache, and fatigue are commonest symptoms of omicron, early data show | The BMJ
https://www.bmj.com/content/375/bmj.n3103
Does COVID-19 cause jaw pain? | AZ Sleep & TMJ Solutions
https://azsleepandtmj.com/does-covid-19-cause-jaw-pain/
SARS-CoV-2 Sequencing and Variants in Washington State
https://www.doh.wa.gov/Portals/1/Documents/1600/coronavirus/data-tables/420-316-SequencingAndVariantsReport.pdf
58
views
(Jan 18th, 2022) My COVID Status
(Jan 18th, 2022) My COVID Status
Today's status.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
10
views
Boosters May Weaken The Immune System Says European Medicine Agency (EMA) | T Cell Exhaustion
Boosters May Weaken The Immune System Says European Medicine Agency (EMA)
European Medicine Agency (EMA) has warned against the overuse of the boosters. Let's review their message and the mechanism of T cell exhaustion behind the message.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Textbook reference:
Inhibition of CD8 + T Cell Responses: T Cell Exhaustion
Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 253). Elsevier Health Sciences. Kindle Edition.
URL list from Tuesday, Jan. 18 2022
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
T cell exhaustion - PubMed
https://pubmed.ncbi.nlm.nih.gov/21739672/#:~:text=T%20cell%20exhaustion%20is%20a,effector%20or%20memory%20T%20cells.
EU drug regulator expresses doubt on need for fourth booster dose | Reuters
https://www.reuters.com/business/healthcare-pharmaceuticals/eu-drug-regulator-says-more-data-needed-impact-omicron-vaccines-2022-01-11/
Interim Statement on COVID-19 vaccines in the context of the circulation of the Omicron SARS-CoV-2 Variant from the WHO Technical Advisory Group on COVID-19 Vaccine Composition (TAG-CO-VAC)
https://www.who.int/news/item/11-01-2022-interim-statement-on-covid-19-vaccines-in-the-context-of-the-circulation-of-the-omicron-sars-cov-2-variant-from-the-who-technical-advisory-group-on-covid-19-vaccine-composition
Repeat Covid Booster Shots Spur Warning on Immune Response, EU Regulators Warn - Bloomberg
https://www.bloomberg.com/news/articles/2022-01-11/repeat-booster-shots-risk-overloading-immune-system-ema-says
EU Drug Regulator Warns Against Overuse of COVID Booster Shots
https://www.voanews.com/a/eu-drug-regulator-warns-against-overuse-of-covid-booster-shots/6395174.html
69
views