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This extreme aging experiment has no danger of developing into a longevity fad but wow. Weird results for castration! How far would you go to live a little longer?

Numerous studies have pointed to the health benefits of coffee, but there have been lingering questions about just what the right amount to drink is, and what type of coffee you is giving us some answers. should be using. Now a new human study Drawing on data from UK Biobank, scientists have once again confirmed the association between coffee and better health outcomes, with ground coffee emerging as the healthiest type. Coffee considered rather unhealthy, but evidence to the was once contrary has been steadily accumulating. Now, the European Society of Cardiology considers drinking 3-4 cups of coffee a day to be moderately beneficial, and the American Heart Association notes that the evidence for coffee's health benefits "stacks. up quickly". Coffee is also associated with a lower risk of type 2 diabetes and Parkinson's disease. While caffeine is by far the most well-known ingredient in coffee, coffee contains more than a hundred biologically active chemicals, including polyphenols, which are potent antioxidants. Like many recent studies, this new study published in the European Journal of Preventive Cardiology makes of UK Biobank, a huge use open repository of various health data on around half a million of British citizens. The sheer size of UK Biobank allows researchers to control for many confounding variables while maintaining considerable statistical power. In this case, covariates included age, gender, ethnicity, BMI, comorbidities such as hypertension and type 2 diabetes, and the lifestyle risk factors of smoking, tea consumption, and alcohol consumption. Participants with a cardiovascular diagnosis at baseline were excluded. The participants' median period was 12.5 years. age was 58 years, and the median follow-up Most importantly, the study considered three popular types of coffee, ground, instant, and decaf. Participants were only able to select one type of coffee, which was a limiting factor, but probably not a critical one. The participants were grouped into six daily intake categories: ranging from 0 cups to more than five. In line with most existing studies, coffee consumption was shown to be generally beneficial. Coffee intake of up to 5 cups per day with significant reductions in the risks of cardiovascular disease, was associated congestive cardiac failure, coronary heart disease, ischemic stroke, and various arrhythmias. The lowest hazard ratio (equivalent to biggest risk reduction) was detected in the 2-3 cups per day group. Ground coffee consistently outperformed the other two types, including with arrhythmias, cardiovascular mortality and all-cause mortality. The ideal dose of ground coffee: seems to be 2-3 cups per day: people who drank this amount of ground coffee were a full 27% less likely to die from all causes during the follow-up period than non-drinkers. Despite the inherent limitations of this study, the results are compelling and in line with previous research: moderate coffee consumption looks like a sensible choice that may confer some protection against cardiovascular disease and all-cause mortality.

The Mediterranean diet, rich in olive oil, vegetables, legumes, fish, and nuts, is widely considered to be of the most healthy and one longevity-friendly diets. Numerous epidemiological studies, and a handful of interventional studies, have linked the Mediterranean diet to various positive health outcomes, including decreased overall mortality along with a lower incidence of cardiovascular diseases and cancer. Now, scientists behind a new study have dug deeper to understand which of the many ingredients of the Mediterranean diet make it healthy, and along the way, they may have found a version of the diet that helps reduce visceral fat and promote weight loss! Pitching two variants of the Mediterranean diet against each other in a randomized controlled trial, scientists have found that a plant-oriented one, which contained more Polyphenols, effective for weight was more. the researchers used an interesting study design Coss. In this new paper, to elucidate the role of polyphenols, a class of phytochemicals known for their antioxidant and anti-inflammatory properties. Polyphenols are abundant in berries, nuts, vegetables, tea, coffee, and many other plant products. For this new randomized controlled trial called DIRECT-PLUS, nearly 300 participants were divided into three groups. The control group ate according to Healthy Dietary Guidelines, while the two study groups were put on a generic Mediterranean diet and on a more plant-oriented Mediterranean diet that had the same amount of calories but almost double the daily intake of polyphenols as the generic group, 440 milligrams us 800 milligrams. Patients in all groups were also put on an identical physical activity regimen. The participants' mean age was 51 and their mean BMI was 31, indicating obesity. 36% were prediabetic, and another 11% were diabetic. The main endpoint of the trial was weight loss, but it was measured in a more sophisticated way than just putting people. on a scale. Instead, MRI technology I was used to quantify abdominal adipose tissues. Following the 18-month trial period, I mean weight loss in the control group was negligible, despite patients being physically active. The two study groups, on the other hand, showed substantial weight loss, with the plant-oriented group losing the most weight. Importantly, the plant-oriented diet was shown to be much more effective in reducing the amount of visceral fat, which is considered more harmful than subcutaneous fat. The researchers went to great lengths to establish the effects of particular dietary components. According to their calculations, higher consumption of green tea, walnuts, and dietary fiber, as well as reduced red meat consumption, were all significantly associated with greater visceral fat loss when adjusted for age and sex. The results of this randomized controlled trial confirm the importance of polyphenol consumption and hint at more plant-based variants of the Mediterranean diet being effective for weight loss.