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Repositioning of Anthelmintic Drugs for the Treatment of Cancers of the Digestive System https://pmc.ncbi.nlm.nih.gov/articles/PMC7404055/ Tumours of the digestive system, their incidence continues to increase. The process discovering and validating novel and effective drugs against these malignancies, lengthy and costly Drug repositioning (drug repurposing), finding new uses for approved drugs, provides the opportunity to expedite promising anti-cancer agents into clinical trials. Some classes of anthelmintics Infections caused by parasitic worms (helminths) Meds have shown pronounced anti-tumor activities Ability to target key oncogenic signal transduction pathways. Benzimidazoles Some have been successfully tested for the treatment of gastrointestinal, liver and pancreatic cancers. Mebendazole Blocks tubulin polymerization, compromise microtubule function Seen to inhibit cell growth and invasion of ascites cell line derived from a primary gastric tumor, whether used alone or in combination with chemotherapeutic Treatment was also successfully tested in five CRC cell lines, showed no cytotoxic activity against three cell lines with non-malignant phenotype Induced remission of lung and lymph node metastases, and a partial remission of liver metastases, in a patient with refractory metastatic colon cancer Showed anti-cancer properties in the treatment of hepatocellular carcinoma Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers https://pmc.ncbi.nlm.nih.gov/articles/PMC9862092/ Albendazole Cytostatic effect on the human cancer cell lines Potential anti-cancer agent also for the treatment of HCC Pancreatic cancer lines Positive mice studies, some early human studies Ivermectin CRC, gastric cancer (vitro and in vivo) Ivermectin, a potential anticancer drug derived from an antiparasitic drug https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/ Mechanisms of action IVM induces different programmed cell death patterns, e.g. apoptosis. Forms of cancer Breast cancer Digestive system cancer Gastric cancer Hepatocellular carcinoma Urinary system cancer Renal cell carcinoma Prostate cancer Hematological cancer Leukemia Reproductive system cancer Cervical cancer Ovarian cancer Brain glioma Glioblastoma Respiratory system cancer Nasopharyngeal carcinoma Lung cancer Melanoma Right to Try https://trumpwhitehouse.archives.gov/briefings-statements/president-donald-j-trump-sign-right-try-legislation-fulfilling-promise-made-expand-healthcare-options-terminal-americans/ Kathleen T Ruddy, MD https://twitter.com/DocRuddy

Ivermectin, a potential anticancer drug derived from an antiparasitic drug https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/ Mechanisms of action IVM induces different programmed cell death patterns in different tumor cells, the main form of IVM induced programmed cell death is apoptosis. Apoptosis Programmed cell death Autophagy Lysosomal-dependent form of programmed cell death. Pyroptosis Inflammatory cell death induced by inflammasomes. Kathleen T Ruddy, MD https://twitter.com/bobanderson77/status/1797002359521866017/video/1 https://rumble.com/v4vk4pw-oncologist-kathleen-rudy-reveals-horse-dewormer-aka-ivermectin-cure-cancer.html https://twitter.com/DocRuddy https://rumble.com/v4vk4pw-oncologist-kathleen-rudy-reveals-horse-dewormer-aka-ivermectin-cure-cancer.html Forms of cancer Breast cancer A malignant tumor produced by gene mutation in breast epithelial cells Digestive system cancer Gastric cancer is one of the most common malignant tumors worldwide. Hepatocellular carcinoma is the fourth leading cause of cancer death worldwide. Urinary system cancer Renal cell carcinoma is a fatal malignant tumor of the urinary system derived from renal tubular epithelial cells. Prostate cancer is a malignant tumor derived from prostate epithelial cells Hematological cancer Leukemia is a type of malignant clonal disease caused by abnormal hematopoietic stem cells Reproductive system cancer Cervical cancer is one of the most common gynecological malignancies Ovarian cancer is a malignant cancer that lacks early clinical symptoms and has a poor therapeutic response. Brain glioma Glioma is the most common cerebral tumor Glioblastoma, median survival time of 14-17 months Respiratory system cancer Nasopharyngeal carcinoma is a malignant tumor derived from epithelial cells of the nasopharyngeal mucosa. Lung cancer has the highest morbidity and mortality among cancers Melanoma The most common malignant skin tumor with a high mortality rate. Other papers Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205794/ Antitumor effects of ivermectin at clinically feasible concentrations support its clinical development as a repositioned cancer drug https://pubmed.ncbi.nlm.nih.gov/32474842/ Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer https://www.nature.com/articles/s41523-021-00229-5 Abstract 2320: Ivermectin suppresses pancreatic cancer via mitochondria dysfunction https://aacrjournals.org/cancerres/article/82/12_Supplement/2320/701043/Abstract-2320-Ivermectin-suppresses-pancreatic Video reviews https://www.youtube.com/watch?v=vCgNaOvICsk https://www.youtube.com/@dr.kathleenruddy1734/videos https://www.youtube.com/watch?v=m_78xfHRHUY https://www.youtube.com/watch?v=jaY2BeNnfy8