Population Genetics, Personal Genomics, History & Human Evolution | Razib Khan | #91
Nick talks to genetics researcher & writer Razib Khan. Razib did graduate work in genetics at the University of California-Davis and recently founded a genomics data startup. He also runs a Substack, "Unsupervised Learning," where he write a lot of fascinating articles, usually on the subjects of human evolutionary & population genetics, personal genomics, and more. Nick and Razib discussed: how the story of human evolution has changed over the past two decades; genomics technology & ancient DNA; Neanderthals, Denisovans & ancient humans; personal genomics (e.g. 23AndMe, Ancestry.com); Razib's experience as a writer on Substack.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at Leafly, a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
0:00:00 Episode Intro
0:05:20 Razib Khan Conversation
38
views
Are Diets High in Protein & Essential Amino Acids Bad for Health?
Molecular physiologist Dr. Dudley Lamming discusses how the protein and amino acid content of diet can affect metabolic health, longevity & aging. In particular, he discusses the effects of branched-chain amino acids on health.
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All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel:
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
13
views
Christian Luscher: How Does Ketamine Work & Is It Addictive? | #90
Nick talks to Christian Luscher, MD, PhD, a neuroscientist at the University of Geneva whose lab studies the cellular mechanisms that underlie drug reinforcement, dependence and addiction. Dr. Luscher talks about the nature of addictive drugs in the brain, how ketamine works, and the latest research from his lab look at how ketamine's unique effects within the brain's reward circuitry enable it to be psychoactive & reinforcing, but have a very low addiction liability (in rodents). He also discusses what this research may mean for the use of ketamine as a therapeutic treatment for depression in humans.
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Thanks!
0:00:00 Episode Intro
0:04:42 Christian Luscher Conversation
72
views
David Anderson: Neuroscience of Aggression, Sex, Behavior, Hormones, Emotion & Consciousness | #89
Nick talks to neuroscientist Dr. David Anderson, a professor at Caltech whose lab studies the neurobiological basis of animal behavior and emotion. They discuss: technologies for understanding cause-and-effect in the brain; neurobiological basis of animal behavior, including aggression/fighting, mating, feeding, and social behavior; how hormones such as estrogen regulate behavior; emotions, feelings, and consciousness; and David's new book, "The Nature of the Beast."
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0:00:00 Episode Intro
0:05:58 David Anderson Conversation
28
views
M&M Clips: Is Ketamine Addictive?
Neurologist & neuroscientist Dr. Christian Luscher describes the latest research from his lab looking at ketamine. How does to work within the brain's "reward circuitry" and what is its addiction liability (in rodents)?
24
views
1
comment
M&M Clips: Neurobiology of Sex Hormones, Estrogen & Testosterone
Neuroscientist Dr. David Anderson discusses what hormones are and how sex hormones like estrogen and testosterone affect brain structures like the hypothalamus to influence animal behavior.
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14
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M&M Clips: Neurobiology of Aggression, Hypothalamus, Optogenetics & Animal Behavior
Neuroscientist Dr. David Anderson explains the neurobiology of aggression by describing video footage where optogenetics is used to control the behavior of mice in real time. He talks about the hypothalamus and how this brain area can drive aggressive behavior, and what neuroscientists are learning about how specific circuits in the brain work.
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34
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Joanna Moncrieff: Depression, Serotonin, SSRIs, Psychiatry & Social Media | #88
Nick talks to psychiatrist Dr. Joanna Moncrieff about depression. What causes it? How do SSRIs work? How well do antidepressants work? What are the risks & benefits of long-term antidepressant use? What is the evidence that depression is caused by a chemical imbalance (too little serotonin) in the brain? How is social media & technology influencing mental health?
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0:00:00 Episode Intro
0:06:20 Joanna Moncrieff Conversation
41
views
Leighton Woodhouse: Sociology, Social Psych, Homelessness, Addiction,Culture,Decline of Civilization
Nick talks to journalist & documentary filmmaker Leighton Woodhouse. They discuss: homelessness & drug addiction; religion & ideology; sociology & social psychology; the social function of laws and norms; economic vs. cultural capital & the "overproduction of elites"; institutional science; civilizational decline & the future of American society.
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0:00:00 Episode Intro
0:06:00 Leighton Woodhouse Conversation
46
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M&M Clips: Long-term Side Effects of Chronic SSRI Antidepressant Use
Psychiatrist Dr. Joanna Moncrieff discusses what is known about the long-term effects of chronic SSRI use. Many people takes these antidepressants for years or even decades, and there may be long-term or persistent side effects, including sexual dysfunction and withdrawal symptoms.
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170
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M&M Clips: Religion, Ideology & Cultural Capital
Journalist & documentary filmmaker Leighton Woodhouse discusses teh social functions of religion, the evolution ideology, college education & the "overproduction of elites," and the concept of cultural capital as distinct from economic capital.
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4
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M&M Clips: Psychedelics & Evolution of Shamanism, Group Ritual Behavior, Mimesis, Symbolic Cognition
Anthropologist Dr. Michael Winkelman the role that psychedelics (e.g. psilocybin mushrooms) have had on the origins and evolution of symbolic cognition, group ritual behavior, mimesis, and shamanism.
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10
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1
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Michael Winkelman: Shamanism, Psychedelics, Cognition, Religion & Evolution of Human Culture | #86
Nick talks to anthropologist Dr. Michael Winkelman, who was a professor at Arizona State University for many years, where he studied topics related to shamanism as practiced by early hunter gatherer societies, and other topics related to human cultural evolution. He is now retired and conducts independent research from Brazil, where he now lives.
They discuss: what shamanism is & the core features of shamanic ritual practices across historical hunter gatherer cultures; how the various ritual practices associated with shamanism were used by forager societies (e.g. symbolism, group dance and drumming) & the use of psychedelics; evolution of shamanism & religion from prehistoric times to the present; role religion and spiritual practices have played in human evolution; how human culture is akin to virtual reality & how human ritual practices help sculpt the narratives that form within human cultures that regulate human behavior; future of religion & spirituality in the modern age & whether the use of psychedelics as entheogenic substances might have a role to play in that.
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0:00:00 Episode Intro
0:00:00 Michael Winkelman Conversation
142
views
Dirk Hoffmeister: Biochemistry of Psilocybin Production, Psychedelic Tryptamines & Magic Mushrooms
Nick talks to pharmaceutical microbiologist Dr. Dirk Hoffmeister, who is professor at the Hans Knöll Institute in Germany. Professor Hoffmeister has a background in botany and mycology, the study of fungi. His lab studies various aspects of fungal biochemistry & molecular biology, including the biochemistry and molecular genetics of psilocybin production in magic mushrooms.
We spoke about various topics in mycology, mostly related to Psilocybe mushrooms. This included: how psilocybin is synthesized from the amino acid tryptophan; the ecological reasons for why some mushrooms produce psilocybin; why magic mushrooms turn a vibrant blue color when they are physically damaged; the production of monoamine oxidase inhibitors (MAOIs) by certain species; the ecology of Psilocybe mushrooms; other areas of mycology that his lab studies.
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0:00:00 Episode Intro
0:04:23 Dirk Hoffmeister Conversation
324
views
Judith Curry: Climatology, Climate Change, Computer Models, Energy, Greenhouse Gas, Politics/Science
Nick talks to climatologist Dr. Judith Curry, the former chair of the School of Earth and Atmospheric Sciences at the Georgia Institute of Technology. Her research interests have included hurricanes, atmospheric modeling, air-sea interactions, and a variety of other areas in climate science. She runs Climate, Etc., an online blog focused on climate science. She is also writing a new book called, “Climate Uncertainty & Risk,” which she described towards the end of the podcast. They discuss: how Earth’s climate has changed over time and how climate scientists measure this; what computer models are used for in climate science and what their strengths & weaknesses are; tropical storms and severe weather events; CO2, methane, and other greenhouse gasses; different forms of energy, such as oil, natural gas, solar, wind, and nuclear; how she thinks about the tradeoffs between different energy sources in terms of their abundance, environmental impact, costs, and other factors; the politicization of climate science and why certain branches of science are especially prone to it.
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0:00:00 Episode Intro
0:04:36 Judith Curry Conversation
84
views
David Cohen: Prescription Drugs, Psychiatric Medicine, Big Pharma & the Medicalization of Everything
Nick talks to Dr. David Cohen, a professor at the UCLA Luskin School of Public Affairs. His research looks at psychoactive drugs (prescribed, licit, and illicit) and their desirable and undesirable effects as socio-cultural phenomena “constructed” through language, policy, attitudes, and social interactions. They discuss: prescription psychiatric drugs, including SSRIs, benzodiazepines and stimulants (e.g. Adderall); the history of how some of the most widely prescribed psychiatric drugs came to be so popular; how pharmaceutical companies go about marketing these drugs and the conditions they aim to treat to both physicians and the public; the quality of the evidence supporting their use; what we are learning about the potential for dependency, long-term health effects, and actual level of benefit that comes from chronic psychiatric drug use; why many psychiatric drugs are increasingly prescribed in combination; and more.
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0:00:00 Episode Intro
0:03:16 David Cohen Conversation
40
views
Shruti Naik: Inflammation, Memory, Epigenetics, Skin Health, Stem Cells, Tissue Repair & Cancer
Nick talks to Dr. Shruti Naik, assistant professor of pathology & medicine at the NYU Langone. Her lab studies the interactions between immune cells, epithelial cells, and microbes in barrier tissues that interface with the environment (e.g. skin, lungs & gut). They discuss: inflammatory memory; how cells store memories of inflammation epigenetically; how skin cell regenerate and repair tissue damage; stem cell biology; cancer, and more.
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0:00:00 Episode Intro
0:04:54 Shruti Naik Conversation
12
views
Margaret McCarthy: Brain Sex Differences, Endocannabinoid Biology, Play Behavior, Cannabis/Pregnancy
Nick talks to neuroscientist Dr. Margaret McCarthy, whose lab at the University of Maryland studies the origins and mechanisms of sex differences in the brain, the endocannabinoid system, and neural basis of animal behavior. They discuss: the nature of sex differences observed in the mammalian brain, including differences in the susceptibility to various diseases and disorders of the brain; differences in juvenile play behavior in males vs. females, and how these can be altered by sex hormones and cannabinoids; sex differences in brain development that lead to sex differences in behavior; how the endocannabinoid system influences brain development and behavior; how cannabis use during pregnancy may influence brain development.
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0:00:00 Episode Intro
0:03:38 Margaret McCathy Conversation
36
views
Matt Ridley: The Origins of the SARS-CoV-2 Virus | #80
Nick talks to science writer Matt Ridley, who most recently published the book, "Viral: The Search for the Origin of COVID-19" together with molecular biologist Dr. Alina Chan. They discussed what is known and still unknown about the origins of the SARS-CoV-2 virus, the latest developments in that mystery which have come to light in the past few months; the relationship between institutional science and politics; whether we are ever likely to know definitively the origins of this virus, and more.
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0:00:00 Episode Intro
0:04:42 Matt Ridley Conversation
38
views
Juvenile Play Behavior & Sex Differences in Brain
Neuroscientist Dr. Margaret McCarthy discusses her research on juvenile play behavior in mammals, sex differences in the brain and behavior, sex hormones, and cannabinoids.
8
views
Sam Banister: Psychedelic Startups, Biotech, Drug Discovery, Psilocybin, DMT, Psychedelics & Society
Nick talks to medicinal chemist Sam Banister, who is co-founder and Chief Science Officer at Psylo, a biotech startup focused on developing next-generation psychedelic medicines. They discuss: the past, present, and future of psychedelic science; Sam's journey from academia to biotech startup co-founder; Alexander Shulgin; psychedelics like psilocybin, DMT, and others; and psychedelics & society.
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0:00:00 Episode Intro
0:04:15 Sam Banister
0:10:03 Serotonin 2B Receptor & Heart Problems
0:15:58 Novel Psychedelic Drug Variants
0:24:03 Stagnation in Psychiatric Drug Development
0:30:41 DMT & DMT Analogues
0:38:20 Starting & Raising Money for Psychedelic Startups
0:47:52 Psychedelic Therapy & Neuroplasticity
0:56:58 Legalization vs. Decriminalization of Psychedelics
1:03:38 Unanswered Questions in Psychedelic Science
1:09:00 Psychedelics & Human Culture
172
views
Kevin Mitchell: Nature/Nurture, Genetics, Personality, Autism, Schizophrenia, Synesthesia, Free Will
Nick talks to neuroscientist & geneticist Dr. Kevin Mitchell about: 'Nature vs. Nurture,' the genetics of brain development, autism & schizophrenia, human brain and psychological variation, synesthesia, agency & free will, and more.
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[https://www.doubleblindmag.com/mindma...]
Organize your digital highlights & notes w/ Readwise (2 months free w/ sub)[https://readwise.io/nickjikomes/]
0:00:00 Episode Intro
0:04:25 Kevin Mitchell, Nature vs. Nurture
0:30:28 Genetics, Twins & Developmental Noise
0:54:51 Neurodevelopmental Genes
1:19:34 Sensory Perception & Synesthesia
1:38:03 Human Agency & Free Will
19
views
Michael Fox: Addiction, Nicotine, Deep Brain Stimulation, Neurotechnology & Parkinson’s Disease
Nick talks to neurologist & neuroscientist Michael Fox, MD, PhD about his recent work mapping out an "addiction remission network" in the brain. They discuss addiction, brain networks involved in addiction, neurotechnologies like Deep Brain Stimulation and Transcranial Magnetic Stimulation, Parkinson's Disease, and more.
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0:00:00 Episode Intro
0:04:05 Michael Fox
30
views
Dominic D'Agostino: Metabolism, Fat, Carbs, Protein, Ketogenic Diet, Nutrition, Blood Sugar & Health
Nick talks to physiologist and neuroscientist Dr. Dominic D'Agostino about human metabolism & nutrition; fats, carbohydrates, sugar, and protein; ketogenic diet, ketosis, BHB supplementation; inflammation and polyunsaturated fats; personal health and metabolism monitoring; and general questions related to the quality of the nutritional information we receive from our institutions.
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0:00:00 Episode Intro
0:04:20 Dominic D'Agostino Intro
0:10:19 Metabolism of Fats, Proteins, Carbs
0:20:16 Diet Composition & Blood Sugar
0:31:15 Ketogenic Diet & Ketosis
0:55:15 Ketone Body Supplements
1:13:23 Saturated & Unsaturated Fats
1:27:04 Inflammation & Fats
1:38:43 Health Monitoring Technology
22
views
Burning Man, Religion & the Evolution of Ritual Behavior
Anthropologist & cognitive scientist Dr. Dimitris Xygalatas discusses how the annual temple burning ritual at Burning Man spontaneously evolved and what it's psychological function is. He also discusses other aspects of religious rituals and how ritual behavior is evolving in the modern world.
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18
views