Cryptostreets

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Chelsea believe Thomas Frank, Enzo Maresca and Roberto De Zerbi all have the right attributes to replace Mauricio Pochettino; Frank is admired for the job he has done at Brentford, Maresca for his playing style at Leicester

Andy Murray beaten in straight sets by Stan Wawrinka in what is likely his last French Open singles match; Murray's fellow Brit Jack Draper knocked out after five-setter against Jesper de Jong; world No 3 Carlos Alcaraz shrugs off any injury fears in breezing past JJ Wolf

Esteban Ocon had an accident with Pierre Gasly on the first lap of the Monaco Grand Prix; Ocon apologised for the incident but team boss Bruno Famin stated Alpine will make a "tough decision", leading to questions about whether something will happen ahead of the Canadian GP on June 7-9

Lewis Hamilton was frustrated Mercedes did not tell him to push on his out-lap after a pit stop in a bid to undercut Max Verstappen; team principal Woolf admitted the team should have been clearer; watch the Canadian Grand Prix live on Sky Sports F1 from June 7-9

Reaction and free match highlights from the Sky Bet Championship play-off final between Leeds United and Southampton at Wembley Stadium on Sunday; Leeds boss Daniel Farke insists his side will use defeat as motivation

New data analysis suggests that NASA and its partners might have discovered more cost-effective ways to tackle the growing issue of orbital debris than previously believed. NASA’s Office of Technology, Policy, and Strategy has released a new report that provides agency leadership with important new insights into how to measure the risks presented by orbital debris. “Growing activity in Earth’s orbit has brought us everything from faster terrestrial communications to a better understanding of our changing climate,” said Charity Weeden who leads NASA’s OTPS. “These blossoming opportunities are resulting in a more crowded space environment. This study is part of NASA’s work to rapidly improve our understanding of that environment as outlined in NASA’s recently released Space Sustainability Strategy, by applying an economic lens to this critical issue.”

The study identifies several emotion regulation systems, offering targets for therapeutic interventions. Ever want to scream during a particularly bad day, but then manage not to? Thank the human brain and how it regulates emotions, which can be critical for navigating everyday life. As we perceive events unfolding around us, the ability to be flexible and reframe a situation impacts not only how we feel, but also our behavior and decision-making. In fact, some of the problems associated with mental health relate to individuals’ inability to be flexible, such as when persistent negative thoughts make it hard to perceive a situation differently. To help address such issues, a new Dartmouth-led study is among the first of its kind to separate activity relating to emotion generation from emotion regulation in the human brain. The findings were published in Nature Neuroscience.

New research documents elevated levels of these metals, needed for energy transition, above and below coal seams in Utah and Colorado. Deposits of designated critical minerals needed to transition the world’s energy systems away from fossil fuels may, ironically enough, be co-located with coal deposits that have been mined to produce the fossil fuel most implicated in climate change. Now, research led by the University of Utah has documented elevated concentrations of a key subset of critical minerals, known as rare earth elements, or REEs, in active mines rimming the Uinta coal belt of Colorado and Utah.

The most recent results from the Global Burden of Disease Study (GBD) 2021, recently published in The Lancet, predict a rise in global life expectancy of 4.9 years for males and 4.2 years for females from 2022 to 2050. Increases are expected to be largest in countries where life expectancy is lower, contributing to a convergence of increased life expectancy across geographies. The trend is largely driven by public health measures that have prevented and improved survival rates from cardiovascular diseases, COVID-19, and a range of communicable, maternal, neonatal, and nutritional diseases (CMNNs).

The Roman Coronagraph Instrument on NASA’s Nancy Grace Roman Space Telescope will help pave the way in the search for habitable worlds outside our solar system by testing new tools that block starlight, revealing planets hidden by the glare of their parent stars. Credit: NASA Getting ready to image faraway planets… Discussing artificial intelligence at NASA… And a milestone for NASA’s supersonic X-plane… A few of the stories to tell you about – This Week at NASA!

New research has shown that the dangerous PF4 antibodies involved in vaccine-induced thrombosis (VITT) and similar disorders from common cold infections share identical molecular structures, highlighting implications for future vaccine development and disease management. New research conducted by Flinders University and global specialists is deepening our knowledge of vaccine-induced immune thrombocytopenia and thrombosis (VITT). During the peak of the COVID-19 pandemic in 2021, VITT was recognized as a new condition linked to adenovirus vector-based vaccines, particularly the Oxford-AstraZeneca vaccine. VITT was found to be caused by an unusually dangerous blood autoantibody directed against a protein termed platelet factor 4 (or PF4). In separate research in 2023, researchers from Canada, North America, Germany, and Italy described a virtually identical disorder with the same PF4 antibody that was fatal in some cases after natural adenovirus (common cold) infection.

A groundbreaking study has mapped a human cerebral cortex fragment in unprecedented detail, finding crucial cellular details and providing a tool for future research. Using more than 1.4 petabytes of electron microscopy (EM) imaging data, researchers have generated a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, providing an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. The human brain is a vastly complex organ and, to date, little is known about its cellular microstructure, including the synaptic and neural circuits it supports. Disruption of these circuits is known to play a role in myriad brain disorders.

Assembled at NASA’s Jet Propulsion Laboratory in Southern California, the Europa Clipper spacecraft has arrived at the Kennedy Space Center in Florida to prepare for its mission to explore Jupiter’s moon Europa. It will study the moon’s surface, ocean, and atmosphere using advanced scientific instruments. NASA’s Europa Clipper, a spacecraft built to investigate Jupiter’s icy moon Europa and its potential to support life, arrived in Florida on Thursday, May 23. The spacecraft, assembled at NASA’s Jet Propulsion Laboratory (JPL) in Southern California, landed aboard a United States Air Force C-17 Globemaster III aircraft at the Launch and Landing Facility at NASA’s Kennedy Space Center.

Suddenly they appear and — like the SARS-CoV-2 coronavirus — can trigger major epidemics: Viruses that nobody had on their radar. They are not really new, but they have changed genetically. New genetic analyses by an international team of researchers suggest that the genetic material exchange between different virus species can create new pathogens with significantly altered, and potentially more threatening, characteristics. The large-scale study was led by virologists from the German Cancer Research Center (DKFZ). “Using a new computer-assisted analysis method, we discovered 40 previously unknown nidoviruses in various vertebrates from fish to rodents, including 13 coronaviruses,” reports DKFZ group leader Stefan Seitz. With the help of high-performance computers, the research team, which also includes Chris Lauber’s working group from the Helmholtz Center for Infection Research in Hanover, has sifted through almost 300,000 data sets. According to virologist Seitz, the fact that we can now analyze such huge amounts of data in one go opens up completely new perspectives.

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