'Dark DNA' Is The Latest Mystery Scientist Found In The World Of Genetics

SeekerPublished: July 10, 2018Updated: July 11, 2018
Published: July 10, 2018Updated: July 11, 2018

When scientists were exploring the sequenced genomes of certain birds and rodents they noticed something odd. A sequenced genome means everything is laid bare, and yet certain DNA sequences were missing, which was unusual because these DNA sequences were very important. They controlled the production of leptin in the birds or the secretion of insulin in the rodents, genes that the scientists knew had to be there, otherwise, they’d have some mighty obese birds and dead rodents on their hands.

What’s more, the scientists studying the rodents found the products of the missing DNA sequences in their cells, so they deduced that the genes weren’t missing, but were somehow hidden. They dubbed these elusive sequences “dark DNA.” This dark DNA may be best described as a blind spot in our DNA sequencing technology. A closer look at the rodent’s genome found a heavily mutated section with abnormally high amounts of guanine and cytosine, two of DNA’s four base molecules, called G and C for short.

It turns out GC rich sequences are difficult to detect, so the researchers missed this mutated pocket of DNA at first. This dark DNA raises questions about how quickly mutations occur, and what genes we may have missed when we sequenced other genomes like our own. There could be more DNA in us than we realized, and we only know about what 1 to 2% of the DNA we have found does.

Also, the researchers considering the rodents found the results of the missing DNA successions in their phones, so they reasoned that the qualities weren't missing, yet were by one means or another covered up. They named these tricky groupings "dim DNA." This dull DNA might be best portrayed as a blindside in our DNA sequencing innovation. A more intensive take a gander at the rat's genome discovered an intensely transformed area with unusually high measures of guanine and cytosine, two of DNA's four base particles, called G and C for short.

This sort of dim DNA has already been found in winged creatures. Researchers have discovered that 274 qualities are "missing" from presently sequenced winged creature genomes. These incorporate the quality for leptin (a hormone that directs vitality adjust), which researchers have been not able to find for a long time. By and by, these qualities have a high GC content and their items are found in the winged creatures' body tissues, despite the fact that the qualities seem, by all accounts, to be absent from the genome successions.
The discovery that some animals thrive despite hugely mutated DNA hidden in their genome is forcing us to rethink some basics of evolution!

The disclosure of such an unusual marvel unquestionably brings up issues about how genomes develop, and what could have been missed from existing genome sequencing ventures. Maybe we have to return and investigate.

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This video, "Scientists are beginning to understand mysterious parts of our DNA. Here’s what they’ve found so far. ", first appeared on seeker.com.

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