dna immunization

bellasmithPublished: December 25, 2017
Published: December 25, 2017

DNA immunization is one of the most straight-forward approaches to elicit an immune reaction against a foreign protein. Differ from the conventional immunization methods, DNA immunization permits in vivo antigen production, bypassing the time-consuming (sometimes also difficult) processes of immunogens (e.g. peptides and recombinant proteins) synthesis and purification. In addition, these in vivo expressed proteins can maximally maintain the naïve structures and go through appropriate post-transcriptional modifications. These properties can contribute to the generation of high-affinity antibodies against the natural conformation of the target antigen, which is a crucial feature for developing therapeutic antibodies. Meanwhile, this approach is also an ideal solution to develop antibodies against membrane proteins or other challenging or problematic antigens. Furthermore, DNA immunization is also a novel tool in the early phases of DNA vaccine development.


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