Vaccine causes multi-organ inflammation

A case of fatal multi-organ inflammation following COVID-19 vaccination

https://www.sciencedirect.com/science/article/pii/S1344622323000548

14-year-old Japanese girl

Healthy and active, athletic team

Died unexpectedly

Two days after receiving the third dose of the BNT1262b2 mRNA COVID-19 vaccine, (10th August 2022)

Autopsy findings

Congestive edema of the lungs

T-cell lymphocytic and macrophage infiltration

Lungs

Pericardium

Myocardium (left atria and left ventricle)

Atrial myopericarditis

Liver

Kidneys

Stomach

Duodenum

Bladder

Diaphragm

No preceding

Infection

Allergy

Drug toxicity exposure
Diagnosis

Post-vaccination

Pneumonia

Myopericarditis

Hepatitis

Nephritis

Gastroenteritis

Cystitis

Myositis

Proximal cause of death

Atrial myopericarditis probably caused fatal arrhythmia,

Leading to cardiac failure and death.

More details

Post-vaccination myocarditis and pericarditis have been increasingly reported

Male adolescents

Higher incidence of pericarditis with a good prognosis

Middle-aged and older patients

More likely to have severe myocarditis

The day after vaccination

Developed a fever of 37.9 °C

Some breathing difficulties

The following morning

Not breathing, pale appearance

In cardiopulmonary arrest when paramedics arrived

Resuscitated

Died 45 hours after the third vaccination.

After the first dose of vaccine on 12th September 2021

Arm pain without fever

Day after the second dose on 3rd October 2021

Fever less than 38 °C

Autopsy findings

No superficial injuries were observed

Heart showed no degeneration or scarring

Both lungs showed severe pulmonary edema and congestion.

A COVID-19 antigen quantification test, negative

Numerous internal organ COVID-19 antigen tests, negative

Serum, negative for adenovirus, cytomegalovirus, influenza A and B, RSV, EBV, enterovirus, parvovirus, HIV

Histological findings

Lymphocyte cellular infiltrates observed in the lungs, pericardium of both atria and adjacent myocardium, liver, kidneys, stomach, duodenum, and diaphragm

Brain showed congestion

Hippocampus a slight lymphocytic infiltrate

Biochemical analysis

Elevated SARS-CoV-2 antibody (43600 U/mL, normal less than 0.80)

Elevated IL-6 (226 pg/mL, normal ≦4.0)

Diagnosis

Vaccine-related multiple-organ inflammation

Vaccine-related myopericarditis, which led to severe arrythmias and progressive heart failure.

Discussion

However, adverse events caused by vaccines have been a problem.