𝗤𝗨𝗔𝗔𝗟𝗨𝗗𝗘𝗦 – The Infamous Hypnotic Sedative // Dangers, Effects, History & More!

In this video I explain everything there is to know about Quaaludes aka Methaqualone! This is a hypnotic sedative made popular by the film "The Wolf of Wall Street" and Bill Cosby.Show more

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This video articulates the gist of the following: Methaqualone is a hypnotic sedative. It was sold under the brand names Quaalude and Sopor among others, which contained 300 mg of methaqualone, and sold as a combination drug under the brand name Mandrax, which contained 250 mg methaqualone and 25 mg diphenhydramine within the same tablet, mostly in Europe. Commercial production of methaqualone was halted in the mid-1980s due to widespread abuse and addictiveness. It is a member of the quinazolinone class. Methaqualone became increasingly popular as a recreational drug and club drug in the late 1960s and 1970s, known variously as "ludes" or "disco biscuits". Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system, similarly to benzodiazepines and barbiturates. When GABA activity is increased, blood pressure drops and breathing and pulse rates slow, leading to a state of deep relaxation. These properties explain why methaqualone was originally mainly prescribed for insomnia. Methaqualone (brand name Quaalude in the US and Mandrax in the UK) is a central nervous system (CNS) depressant of the quinazolinone class that acts as a sedative and hypnotic. The sedative–hypnotic activity of methaqualone was first noted by researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan. Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system, similarly to benzodiazepines and barbiturates. When GABA activity is increased, blood pressure drops and breathing and pulse rates slow, leading to a state of deep relaxation. These properties explain why methaqualone was originally mainly prescribed for insomnia. Methaqualone was not recommended for use while pregnant and is in pregnancy category. Methaqualone peaks in the bloodstream within several hours, with a half-life of 20–60 hours. While the salt methaqualone hydrochloride is typically used clinically, methaqualone free-base was also marketed, namely as the methaqualone component of Mandrax, a combination drug which contained 250 mg methaqualone and 25 mg diphenhydramine within the same tablet. Oral dosage forms of methaqualone hydrochloride were manufactured as capsules, whereas oral dosage forms of methaqualone free-base were manufactured as tablets. Despite prior speculation, a 2015 study demonstrates that methaqualone exhibits distinct functional properties at the GABA receptor sites compared with other allosteric modulators, and it mediates these through a different mechanism than the barbiturates and benzodiazepines that it historically has been lumped together with. These distinctions could contribute to the reported differences in the in vivo effects induced by methaqualone and classic CNS depressants. In any case, the multifaceted functionality of methaqualone at GABAA receptors seems to be at the root of its clinical efficacy, as well as the addiction liability and recreational use associated with the drug.
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#Methaqualone #Sedative #Quaaludes
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⚠⚠**DISCLAIMER / WARNING**⚠⚠
No illicit substances were used in this video! This video is for informational and educational purposes only; do not try this substance or any other substance, whether it be legal or not. This video has been created strictly for education and harm reduction; to help people remain safe by properly educating them about the dangers & truths in an entertaining & artistic way. The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information contained in this video is for general information & entertainment purposes only. By viewing this video, you agree to never recreate anything discussed whatsoever. Do not replicate anything you see or hear in this video (or any other videos posted to this channel). This video/channel does not condone or glorify the usage of drugs. Thank you & stay safe :)
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