How Did the SARS-CoV-2 Virus Originate? | Alex Washburne | #97
Nick talks to mathematical biologist Dr. Alex Washburne about the origins of the SARS-CoV-2 virus.
Audio version and more information here: https://mindandmatter.substack.com/p/how-did-the-sars-cov-2-virus-originate#details
471
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Dirk Hoffmeister: Biochemistry of Psilocybin Production, Psychedelic Tryptamines & Magic Mushrooms
Nick talks to pharmaceutical microbiologist Dr. Dirk Hoffmeister, who is professor at the Hans Knöll Institute in Germany. Professor Hoffmeister has a background in botany and mycology, the study of fungi. His lab studies various aspects of fungal biochemistry & molecular biology, including the biochemistry and molecular genetics of psilocybin production in magic mushrooms.
We spoke about various topics in mycology, mostly related to Psilocybe mushrooms. This included: how psilocybin is synthesized from the amino acid tryptophan; the ecological reasons for why some mushrooms produce psilocybin; why magic mushrooms turn a vibrant blue color when they are physically damaged; the production of monoamine oxidase inhibitors (MAOIs) by certain species; the ecology of Psilocybe mushrooms; other areas of mycology that his lab studies.
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0:00:00 Episode Intro
0:04:23 Dirk Hoffmeister Conversation
324
views
Sam Banister: Psychedelic Startups, Biotech, Drug Discovery, Psilocybin, DMT, Psychedelics & Society
Nick talks to medicinal chemist Sam Banister, who is co-founder and Chief Science Officer at Psylo, a biotech startup focused on developing next-generation psychedelic medicines. They discuss: the past, present, and future of psychedelic science; Sam's journey from academia to biotech startup co-founder; Alexander Shulgin; psychedelics like psilocybin, DMT, and others; and psychedelics & society.
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0:00:00 Episode Intro
0:04:15 Sam Banister
0:10:03 Serotonin 2B Receptor & Heart Problems
0:15:58 Novel Psychedelic Drug Variants
0:24:03 Stagnation in Psychiatric Drug Development
0:30:41 DMT & DMT Analogues
0:38:20 Starting & Raising Money for Psychedelic Startups
0:47:52 Psychedelic Therapy & Neuroplasticity
0:56:58 Legalization vs. Decriminalization of Psychedelics
1:03:38 Unanswered Questions in Psychedelic Science
1:09:00 Psychedelics & Human Culture
172
views
M&M Clips: Long-term Side Effects of Chronic SSRI Antidepressant Use
Psychiatrist Dr. Joanna Moncrieff discusses what is known about the long-term effects of chronic SSRI use. Many people takes these antidepressants for years or even decades, and there may be long-term or persistent side effects, including sexual dysfunction and withdrawal symptoms.
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170
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Metabolic Switching, Fasting, Ketosis, Neuroplasticity, Diet, Neurodegenerative Disease Mark Mattson
bout the Guest: Mark Mattson, PhD is a semi-retired neuroscientist at Johns Hopkins who ran a research lab at the NIH for many years. He wrote the book, "The Intermittent Fasting Revolution."
Episode Summary: Nick and Dr. Mattson discuss: intermittent fasting & diet; ketosis & metabolic switching; aging & neurodegenerative disease; exercise, stress, and neuroplasticity; and more.
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#metabolism #fasting #ketosis #ketogenicdiet #science #biology #medicine #parkinsons #alzheimers #aging #food #health #exercise #stress #podcast
108
views
Cellular Aging, Taurine, Nutrition, Senescence, Longevity, Mitochondria, Metabolism | Vijay Yadav
Nick talks to molecular physiologist Dr. Vijay Yadav, an assistant professor at Columbia University whose lab studies the molecular & cell biology of aging, nutrition, and longevity. They discuss: the cell biology of aging; how nutrients affect aging & disease; the atypical amino acid taurine & its effects on aging; taurine clinical trials & supplementation; diet, nutrition & anti-aging effects; and more.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
109
views
Michael Winkelman: Shamanism, Psychedelics, Cognition, Religion & Evolution of Human Culture | #86
Nick talks to anthropologist Dr. Michael Winkelman, who was a professor at Arizona State University for many years, where he studied topics related to shamanism as practiced by early hunter gatherer societies, and other topics related to human cultural evolution. He is now retired and conducts independent research from Brazil, where he now lives.
They discuss: what shamanism is & the core features of shamanic ritual practices across historical hunter gatherer cultures; how the various ritual practices associated with shamanism were used by forager societies (e.g. symbolism, group dance and drumming) & the use of psychedelics; evolution of shamanism & religion from prehistoric times to the present; role religion and spiritual practices have played in human evolution; how human culture is akin to virtual reality & how human ritual practices help sculpt the narratives that form within human cultures that regulate human behavior; future of religion & spirituality in the modern age & whether the use of psychedelics as entheogenic substances might have a role to play in that.
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0:00:00 Episode Intro
0:00:00 Michael Winkelman Conversation
142
views
Anxiety, Obsessive Compulsive Disorder, Microglia, WWII Orphan to the Nobel Prize | Mario Capecchi
Dr. Mario Capecchi is a professor of genetics at the University of Utah & Nobel laureate. He discussed: his latest work in neurobiology, looking at the role of microglia in anxiety & Obsessive Compulsive Disorder (OCD); his Nobel Prize-winning work in molecular genetics; molecular biology & genetics; his childhood experiences as an orphan in Italy during World War II; immigrating to the US; his education & scientific career; his exercise & diet; advice for aspiring scientists; and more.
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Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
121
views
Martin Kulldorff: Public Health, Pandemics, Epidemiology, SARS-CoV-2 & COVID Public Policy | #61
Martin Kulldorff, PhD is an epidemiologist & biostatistician who has been studying infectious diseases for over two decades. He was a professor at Harvard Medical School for many years, a member of the FDA’s Drug Safety & Risk Management Advisory Committee, and a former consultant for the Centers for Disease Control. In 2020, Dr. Kulldorff co-authored the Great Barrington Declaration, a document criticizing the use of society-wide lockdowns for COVID-19 and advocating for a strategy of focused protection for high-risk people.
Nick and Dr. Kulldorff discussed a variety of topics related to the COVID pandemic, including the nature of how the SARS-CoV-2 virus spreads compared to other pathogens, how our public health strategy was implemented & his thoughts on how we could have handled the pandemic better, vaccine-induced immunity vs. natural immunity, vaccine efficacy, how and why various countries differed in their approach to COVID, and the health of our scientific & public health institutions in the US.
87
views
Psychedelics, Depression, Psychotherapy, SSRIs, Human Clinical Experience of Psychedelic Medicine
Nick talks to Dr. Alan Davis, a clinical psychologist and Director of the Center for Psychedelic Drug Research & Education at Ohio State University. They discuss: the effectiveness of mainstream forms of psychotherapy and antidepressant medications (SSRIs) for depression; psychedelic medicine & psilocybin-assisted psychotherapy; the relevance of the subjective effects of psychedelics for their therapeutic effects; FDA approval for MDMA- and psilocybin-assisted psychotherapy in the coming years; and more.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
85
views
Effects of Marijuana, THC & Cannabinoids on Brain Development
What role does the endocannabinoid system play in brain development, and how does exposure to THC and other cannabinoids affect brain development. Neuroscientist Dr. Matthew Hill discusses what we know about how cannabinoids influence brain development.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
102
views
Hormonal Contraception, Sex Hormones, Menstruation, Pregnancy, Puberty, Estrogens, Androgens
Dr. Adriene Beltz is an associated professor of psychology at the University of Michigan who studies the effects of sex hormones & hormonal contraception on human cognition and the brain. They discuss: sex hormones (androgens & estrogens); hormonal regulation of menstruation, puberty, and pregnancy; common forms of hormonal birth control & how they work; effects of sex hormones & hormonal birth control on cognition & the brain; and more.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
91
views
Robert Greene: The Psychology of Power & Social Status | #66
Nick speaks to writer Robert Greene, who is the author of several books exploring different, and sometimes dark, aspects of human psychology. The discussion focuses on the subject of his first book, "The 48 Laws of Power."
They discuss what power is and how it's used. Different psychological traits that people who successfully acquire power tend to have. Strategies that have been useful throughout history for acquiring more power, as well as those that lead to a loss of power. Robert talks the political scientist Niccolo Machiavelli, and how he is often misunderstood. He also gave his perspective on some influential people with power today, including Vladimir Putin, Angela Merkel, and Elon Musk.
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0:00:00 Episode Intro
0:04:53 Robert Greene Intro
0:07:25 Niccolo Machiavelli
0:14:25 Structure of Greene's Books
0:25:03 Power & Relationships
0:30:08 Deceit, Self-Deception & Language
0:41:24 PT Barnum & Capturing Attention
0:50:36 Protecting Yourself From Predation
1:00:57 Robert's Historical Research Process
1:15:00 Powerful Modern World Leaders
1:24:45 Elon Musk & Final Thoughts
91
views
Psychedelics, Plasticity, Critical Periods, Social Learning, Psilocybin, MDMA, Ketamine | Gül Dölen
Nick talks to Gül Dölen, MD, PhD., a neuroscientist at Johns Hopkins University whose lab studies social behavior, synaptic plasticity, psychedelics & evolution. They discuss: What drugs like LSD, psilocybin, ketamine, MDMA, and ibogaine have in common in terms of their molecular effects in the brain; why Dr. Gül Dölen believes all of these drugs can be described as "psychedelics"; the relationship between psychedelics and neuroplasticity vs. metaplasticity; how addictive drugs are similar to and different from psychedelics; social reward learning in rodents & critical periods of plasticity; the subjective effects of psychedelics; novel psychedelic drug development; human social behavior, mental health, and psychiatry; and more.
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ABOUT Nick Jikomes:
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76
views
Evolution of Human Behavior, Anatomy & Diet, Homo naledi & the Cave of Bones | John Hawks | #126
Dr. John Hawks is a paleoanthropologist and professor of anthropology at the University of Wisconsin-Madison. They discuss: the evolution of human behavior, diet, anatomy, and culture; Neanderthals, Denisovans, Homo erectus, and other species; the latest discoveries related to Homo naledi, which was the subject of the Netflix documentary, "Cave of Bones."
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80
views
Judith Curry: Climatology, Climate Change, Computer Models, Energy, Greenhouse Gas, Politics/Science
Nick talks to climatologist Dr. Judith Curry, the former chair of the School of Earth and Atmospheric Sciences at the Georgia Institute of Technology. Her research interests have included hurricanes, atmospheric modeling, air-sea interactions, and a variety of other areas in climate science. She runs Climate, Etc., an online blog focused on climate science. She is also writing a new book called, “Climate Uncertainty & Risk,” which she described towards the end of the podcast. They discuss: how Earth’s climate has changed over time and how climate scientists measure this; what computer models are used for in climate science and what their strengths & weaknesses are; tropical storms and severe weather events; CO2, methane, and other greenhouse gasses; different forms of energy, such as oil, natural gas, solar, wind, and nuclear; how she thinks about the tradeoffs between different energy sources in terms of their abundance, environmental impact, costs, and other factors; the politicization of climate science and why certain branches of science are especially prone to it.
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0:00:00 Episode Intro
0:04:36 Judith Curry Conversation
84
views
Peripheral Nervous System in Health & Disease, Gut & Enteric Nervous System, Exercise, Plasticity
Dr. Moses Chao is a professor at the New York University School of Medicine. His lab studies how the environment, neuronal activity, inflammation, injury and disease affect the nervous system. They discuss topics related to his new book, "Peripheral: How Your Nervous System Predicts and Protects Against Disease." Topics include: how the peripheral nervous system differs from the central nervous system; the enteric nervous system & gut health; pain sensation; exercise & neuroplasticity; neurodegenerative disease; and more.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
95
views
Endocannabinoids, Stress, Exercise, Cortisol, Anxiety, Marijuana & Brain Development | Matthew Hill
Nick talks to Dr. Matthew Hill, a neuroscientist at the University of Calgary whose lab studies how the endocannabinoid system and cannabis (marijuana) influence the brain & behavior. They discuss: endocannabinoid biology; endocannabinoid regulation of stress & anxiety; endocannabinoids & exercise; how marijuana & THC influence brain development; and more.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
67
views
Alcohol Toxicity, Vaping vs Smoking, Tobacco, Nicotine, Marijuana, Terpenes, Toxicology | Echo Rufer
Nick talks to board-certified toxicologist Dr. Echo Rufer. The conversation starts with a brief overview of what the science of toxicology is all about & a little bit about alcohol toxicity. They then discuss: differences between vaping and smoking; what toxins are produced through the combustion of plant material, especially tobacco & marijuana; cannabinoids like THC & CBD, as well as cannabis terpenes; relationship between dose, method of consumption & toxicity of chemical compounds; causes of the vaping-associated pulmonary injury (VAPI) associated with the vitamin E acetate that was found in some illicit market cannabis vape products; best ways to minimize toxin exposure for people who inhale plant-based consumer products such as tobacco or nicotine products or marijuana.
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ABOUT Nick Jikomes:
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60
views
Psychedelics, Microdosing Psilocybin, Stress Resilience, Anxiety & OCD | Mikael Palner
Mikael Palner, PhD is a neuroscientist at the University of Souther Denmark. His lab studies the neuronal circuits involved in obsessive compulsive disorder and anxiety . They investigate the effects of serotonergic psychedelic and non-psychedelic drugs that increase neuronal plasticity. They discuss: psychedelics & the brain; the neuroscience of stress, anxiety & compulsive behavior; microdosing psilocybin; and more.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
95
views
1
comment
Marijuana, Plant Chemistry, Terpenes, Volatile Sulfur Compounds, Cannabis Industry, Aroma of Weed
Nick talks to Dr. Iain Oswald, who has a PhD in chemistry from the University of Texas-Dallas and is principal scientist Abstrax Tech, a cannabis research and product development company. He is an expert in using cutting edge analytical chemistry techniques to study plant chemistry and has done a lot of work to decipher the chemistry of commercial cannabis, including lesser-known compounds found in the essential oils of marijuana plants and how these relate the sensory qualities of marijuana.
They discuss: the aroma of cannabis & the chemical compounds that dictate different aspects of its aroma; consumer preferences when it comes to marijuana aroma; terpenes, which are volatile compounds abundant in the plant world; his research on volatile sulfur compounds, which are found in nature in things like garlic and the aerosols produced by skunks, and how lesser-known cannabis compounds in this chemical family relate to some of the pungent, gassy/skunky odors commonly associated with marijuana; his journey from academia into the private sector, and what’s on the horizon for cannabis research.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
59
views
Evolution & Neural Basis of Monogamy, Pheromones, Parenting Behavior
Neuroscientist Dr. Devanand Manoli talks about the evolution of monogamy is prairie voles and other species, how pheromones like oxytocin work, and parenting behavior in monogamous species.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
53
views
Cannabis Lab Testing, THC, CBD, Cannabinoids, Terpenes, Pesticides, Heavy Metals, Marijuana Industry
Nick talks with Nick Mosley, who is CEO of a cannabis testing lab called Confidence Analytics, which conducts analytical testing for legal cannabis products in Washington & California. They discuss: how analytical testing for cannabis products works; THC, CBD, and cannabinoid content; terpenes; pesticides, heavy metals, and microbial contaminants; the phenomenon of THC inflation & lab shopping in the legal marijuana industry; how consumers can discern whether cannabis products are safe & consistent.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
60
views
Psychedelics, Neuroplasticity, LSD, Psilocybin, Ketamine, MDMA, Psychedelic Science | Bryan Roth
Nick talks to Bryan Roth, MD, PhD, a Professor of Pharmacology at the University of North Carolina. Dr. Roth has been studying the molecular mechanisms of psychedelics since the 1980s. They discuss: serotonin 2A receptors in the mammalian brain; psychedelics & neuroplasticity; classic psychedelics (e.g. LSD, psilocybin, DMT) compared to drugs like ketamine & MDMA; TrkB receptors & BDNF; engineering novel drugs & psychiatric treatment methods; latest findings in psychedelic science.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
61
views
Terrence McKenna & the Psychedelic Experience
Dennis McKenna, PhD discusses his brother Terence McKenna's history with psychedelics & magic mushrooms, including whether he stopped taking them in his adult life. He also talks about the therapeutic efficacy of the subjective effects of psychedelics, and reflects on what he misses most about Terence McKenna since he passed away in 2000.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
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