Mind & Matter Podcast

bout the Guest: Mark Mattson, PhD is a semi-retired neuroscientist at Johns Hopkins who ran a research lab at the NIH for many years. He wrote the book, "The Intermittent Fasting Revolution." Episode Summary: Nick and Dr. Mattson discuss: intermittent fasting & diet; ketosis & metabolic switching; aging & neurodegenerative disease; exercise, stress, and neuroplasticity; and more. More content on the science of diet & metabolism: [ https://substack.com/search/metabolis... ] LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison. #metabolism #fasting #ketosis #ketogenicdiet #science #biology #medicine #parkinsons #alzheimers #aging #food #health #exercise #stress #podcast

Dr. Moses Chao is a professor at the New York University School of Medicine. His lab studies how the environment, neuronal activity, inflammation, injury and disease affect the nervous system. They discuss topics related to his new book, "Peripheral: How Your Nervous System Predicts and Protects Against Disease." Topics include: how the peripheral nervous system differs from the central nervous system; the enteric nervous system & gut health; pain sensation; exercise & neuroplasticity; neurodegenerative disease; and more. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/how-to-support-mind-and-matter ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Anthropologist Dr. David Puts discusses what's known about biological factors that influence sexual orientation in humans, including factors like sex hormone concentrations during pregnancy, the number of male offspring females have, and effects of the female immune system on male development in utero. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/how-to-support-mind-and-matter ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Mikael Palner, PhD is a neuroscientist at the University of Souther Denmark. His lab studies the neuronal circuits involved in obsessive compulsive disorder and anxiety . They investigate the effects of serotonergic psychedelic and non-psychedelic drugs that increase neuronal plasticity. They discuss: psychedelics & the brain; the neuroscience of stress, anxiety & compulsive behavior; microdosing psilocybin; and more. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/how-to-support-mind-and-matter ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Dr. John Hawks is a paleoanthropologist and professor of anthropology at the University of Wisconsin-Madison. They discuss: the evolution of human behavior, diet, anatomy, and culture; Neanderthals, Denisovans, Homo erectus, and other species; the latest discoveries related to Homo naledi, which was the subject of the Netflix documentary, "Cave of Bones." LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Dr. Mario Capecchi is a professor of genetics at the University of Utah & Nobel laureate. He discussed: his latest work in neurobiology, looking at the role of microglia in anxiety & Obsessive Compulsive Disorder (OCD); his Nobel Prize-winning work in molecular genetics; molecular biology & genetics; his childhood experiences as an orphan in Italy during World War II; immigrating to the US; his education & scientific career; his exercise & diet; advice for aspiring scientists; and more. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/how-to-support-mind-and-matter?utm_source=%2Fsearch%2Fsupport&utm_medium=reader2 ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Dr. Adriene Beltz is an associated professor of psychology at the University of Michigan who studies the effects of sex hormones & hormonal contraception on human cognition and the brain. They discuss: sex hormones (androgens & estrogens); hormonal regulation of menstruation, puberty, and pregnancy; common forms of hormonal birth control & how they work; effects of sex hormones & hormonal birth control on cognition & the brain; and more. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

What role does the endocannabinoid system play in brain development, and how does exposure to THC and other cannabinoids affect brain development. Neuroscientist Dr. Matthew Hill discusses what we know about how cannabinoids influence brain development. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/how-to-support-mind-and-matter ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Nick talks to Dr. Matthew Hill, a neuroscientist at the University of Calgary whose lab studies how the endocannabinoid system and cannabis (marijuana) influence the brain & behavior. They discuss: endocannabinoid biology; endocannabinoid regulation of stress & anxiety; endocannabinoids & exercise; how marijuana & THC influence brain development; and more. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/how-to-support-mind-and-matter ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Nick talks to molecular physiologist Dr. Vijay Yadav, an assistant professor at Columbia University whose lab studies the molecular & cell biology of aging, nutrition, and longevity. They discuss: the cell biology of aging; how nutrients affect aging & disease; the atypical amino acid taurine & its effects on aging; taurine clinical trials & supplementation; diet, nutrition & anti-aging effects; and more. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/how-to-support-mind-and-matter ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Neuroscientist Dr. Gul Dolen discusses the subjective effects of psychedelics, whether they may have therapeutic value, the importance of context in their effects on metaplasticity & the brain, and whether non-hallucinogenic psychedelic drug derivatives will be effective therapeutics. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Nick talks to Gül Dölen, MD, PhD., a neuroscientist at Johns Hopkins University whose lab studies social behavior, synaptic plasticity, psychedelics & evolution. They discuss: What drugs like LSD, psilocybin, ketamine, MDMA, and ibogaine have in common in terms of their molecular effects in the brain; why Dr. Gül Dölen believes all of these drugs can be described as "psychedelics"; the relationship between psychedelics and neuroplasticity vs. metaplasticity; how addictive drugs are similar to and different from psychedelics; social reward learning in rodents & critical periods of plasticity; the subjective effects of psychedelics; novel psychedelic drug development; human social behavior, mental health, and psychiatry; and more. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Clinical psychologist & psychedelic research Dr. Alan Davis summaries research to-date on psilocybin-assisted psychotherapy in humans. How does it work? What are the major findings for things like depression?

Nick talks to Dr. Alan Davis, a clinical psychologist and Director of the Center for Psychedelic Drug Research & Education at Ohio State University. They discuss: the effectiveness of mainstream forms of psychotherapy and antidepressant medications (SSRIs) for depression; psychedelic medicine & psilocybin-assisted psychotherapy; the relevance of the subjective effects of psychedelics for their therapeutic effects; FDA approval for MDMA- and psilocybin-assisted psychotherapy in the coming years; and more. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Nick talks to Bryan Roth, MD, PhD, a Professor of Pharmacology at the University of North Carolina. Dr. Roth has been studying the molecular mechanisms of psychedelics since the 1980s. They discuss: serotonin 2A receptors in the mammalian brain; psychedelics & neuroplasticity; classic psychedelics (e.g. LSD, psilocybin, DMT) compared to drugs like ketamine & MDMA; TrkB receptors & BDNF; engineering novel drugs & psychiatric treatment methods; latest findings in psychedelic science. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Dennis McKenna, PhD discusses his brother Terence McKenna's history with psychedelics & magic mushrooms, including whether he stopped taking them in his adult life. He also talks about the therapeutic efficacy of the subjective effects of psychedelics, and reflects on what he misses most about Terence McKenna since he passed away in 2000. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Nick talks to ethnopharmacologist Dr. Dennis McKenna, who is the brother of psychonaut Terence McKenna and author of the book, "The Brotherhood of the Screaming Abyss." They discuss: the lives and psychedelic adventures of Dennis & Terence McKenna; experiences with psilocybin mushrooms & DMT; Carl Jung & psychology; the medical relevance of subjective psychedelic experiences; drugs, culture & society; and more. LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Nick talks to Daniel Karlin, MD, a board-certified physician in psychiatry, addiction medicine & clinical informatics who is the Chief Medical Officer at MindMed. They discuss: psychiatry; incentives in scientific & medical research; healthcare & mental health; psychedelics; LSD for anxiety; MDMA for autism; ibogaine derivatives for addiction; patient access & care; and more. Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off: [https://www.lumen.me/shop?fid=8731&ut...] LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Nick talks to chemist & food scientist Dr. Selina Wang about: food quality & purity; cooking oils (avocado, olive, vegetable, etc.); fruits & vegetables; oxidation & purity of cooking oils; how to identify high quality, pure foods to purchase; and more. Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off: [https://www.lumen.me/shop?fid=8731&ut...] LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison. 0:00:26 Intro 0:06:11 What is Food Quality? 0:15:51 Health Effects of Oxidized Oils 0:22:08 Different Types of Olive Oil 0:30:29 Refined Oils 0:40:27 Olive Oil Study 0:47:28 Best Way to Store Olive Oil 0:54:02 Study Results (Quality & Purity) 1:00:13 Best Brands 1:06:19 Avocado Oil Study 1:13:57 Enforcement of Standards

Nick talks to Dr. Luc van Loon, Professor of Exercise Physiology & Nutrition at Maastricht University, about protein quality, amino acids, protein supplements, animal vs. plant protein, and related topics. Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off: [https://www.lumen.me/shop?fid=8731&ut...] LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Nick talks to Dr. Luc van Loon, Professor of Exercise Physiology & Nutrition at Maastricht University, about topics in exercise science, health & nutrition. They discuss: macronutrients & energy; protein quality & digestibility; endurance & resistance training; plant vs. animal protein; muscle conditioning & muscle fibers; sleep & aging; muscle physiology & metabolism; and more. Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off: [https://www.lumen.me/shop?fid=8731&ut...] LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Nick talks to Dr. Iain Oswald, who has a PhD in chemistry from the University of Texas-Dallas and is principal scientist Abstrax Tech, a cannabis research and product development company. He is an expert in using cutting edge analytical chemistry techniques to study plant chemistry and has done a lot of work to decipher the chemistry of commercial cannabis, including lesser-known compounds found in the essential oils of marijuana plants and how these relate the sensory qualities of marijuana. They discuss: the aroma of cannabis & the chemical compounds that dictate different aspects of its aroma; consumer preferences when it comes to marijuana aroma; terpenes, which are volatile compounds abundant in the plant world; his research on volatile sulfur compounds, which are found in nature in things like garlic and the aerosols produced by skunks, and how lesser-known cannabis compounds in this chemical family relate to some of the pungent, gassy/skunky odors commonly associated with marijuana; his journey from academia into the private sector, and what’s on the horizon for cannabis research. Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off: [https://www.lumen.me/shop?fid=8731&ut...] LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.

Nick talks to board-certified toxicologist Dr. Echo Rufer. The conversation starts with a brief overview of what the science of toxicology is all about & a little bit about alcohol toxicity. They then discuss: differences between vaping and smoking; what toxins are produced through the combustion of plant material, especially tobacco & marijuana; cannabinoids like THC & CBD, as well as cannabis terpenes; relationship between dose, method of consumption & toxicity of chemical compounds; causes of the vaping-associated pulmonary injury (VAPI) associated with the vitamin E acetate that was found in some illicit market cannabis vape products; best ways to minimize toxin exposure for people who inhale plant-based consumer products such as tobacco or nicotine products or marijuana. Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off: [https://www.lumen.me/shop?fid=8731&ut...] LEARN MORE & SUPPURT M&M: All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.