"mRNA technology is a good fit for gene editing. We want to make these editing proteins for just a short period of time to modify the genome. And producing the editing enzymes transiently helps to reduce the potential for off-target effects."
"mRNA technology is a good fit for gene editing. We want to make these editing proteins for just a short period of time to modify the genome. And producing the editing enzymes transiently helps to reduce the potential for off-target effects."
Closing quote
Seng Cheng, Vice President and Chief Scientific Officer of the Rare Disease Research Unit at Pfizer.
.
.
Unlocking the Power of Our Body's Protein Factory - mRNA Part 2 | Pfizer
https://www.pfizer.com/news/behind-the-science/unlocking-power-our-bodys-protein-factory
.
Intracellular Delivery of mRNA for Cell-Selective CRISPR/Cas9 Genome Editing using Lipid Nanoparticles
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200801
.
Jenifer Dudna (2015) CRISPR CAS9 Uses (TED TALK) https://youtu.be/TdBAHexVYzc
.
Biotechnology: Genetically Engineered Pathogens (The Counterproliferation Papers, Future Warfare Series No. 53) USAF COUNTERPROLIFERATION CENTER MAXWELL AFB AL (US BIOWARFARE MANIFESTO ?!)
https://apps.dtic.mil/sti/citations/ADA556597
.
PFIZER: WHAT IS mRNA? - To enter cells smoothly, mRNA travels within a protective bubble called a Lipid Nanoparticle. Once inside, our cells read the mRNA as a set of instructions, building proteins.
https://www.pfizer.com/science/innovation/mrna-technology
.
Our cells are prolific protein factories.
And mRNA plays a key role in this process.
Messenger RNA is a molecule found in every living being. If DNA is our instruction manual for life, then mRNA is a single-page photocopy from this book—carrying genetic information for a specific protein.
Turning your body
into medicine factories
Scientists are looking to apply mRNA across a broad range of diseases. What makes it so versatile? The answer comes down to two basic biological principles:
Using these mRNA instructions, our cells make the proteins we need to sustain life.
https://www.pfizer.com/news/behind-the-science/how-once-little-known-molecule-disrupting-medicine
.

Unlocking the Power of
Our Body’s Protein Factory
By Sachi Fujimori | June 2022
"mRNA technology is a good fit for gene editing. We want to make these editing proteins for just a short period of time to modify the genome. And producing the editing enzymes transiently helps to reduce the potential for off-target effects." https://www.pfizer.com/news/behind-the-science/unlocking-power-our-bodys-protein-factory
.

The optimal delivery of mRNA by using lipid nanoparticles (LNPs) can be achieved through a rational design process and high-throughput screening of a lipid library. The spatiotemporally controlled delivery of mRNA-encoding CRISPR/Cas9 can provide an effective and convenient approach for cell-selective genome editing and targeted gene therapy.
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200801
.
The technology was developed from a natural defence system that pastes a virus's genetic material next to CRISPR sequences in a bacterium's genome, enabling the cell to remember the invader.
Proteins, known as Cas enzymes, use a CRISPR sequence like a Wanted Poster. They recognise and cut up the virus if it tries to reinfect.
https://www.google.com/amp/s/www.sciencefocus.com/the-human-body/rna-in-crispr-and-mrna-vaccines/amp/
.
.
WHY IS @NONVAXER420 THE ONLY RUMBLE CHANNEL EXPOSING (BIODIGITAL CONVERGENCE) LINKED WITH NANO-TECHNOLOGY, POLICIES, DIGITAL-ID,CBDC, DNA-DATA-MARKETPLACE & YOU'RE DIGITAL FUTURE? https://rumble.com/v2wcfvu-june-25-2023.html
-
1:13:59
Tactical Advisor
3 hours agoVault Room Tour/Unboxing- Vault Room Live Stream
13K2 -
1:11:28
The Squad
10 hours agoArsenal's Huge Summer🚨Olise to Man Utd DEAL✅ Osimhen to Arsenal or Chelsea☑️ UCL Final Preview
23.9K6 -
56:23
Trumpet Daily
23 hours ago $1.10 earnedCohen Is Free to Lie and Steal, but Trump Is Guilty of Something - Trumpet Daily | May 31, 2024
15.8K40 -
8:26
MichaelBisping
22 hours agoBISPING CHOKES OUT STEVE-O! | JACKASS STAR PUT TO SLEEP BY UFC CHAMP! *FULL VIDEO*
37.8K12 -
20:00
Clownfish TV
21 hours agoGoogle Hurt ITSELF in Its Confusion!
49.1K49 -
24:20
Brewzle
1 day agoWe Went Unicorn Bourbon Hunting In Louisville, KY
55.7K8 -
35:39
Degenerate Jay
1 day agoGoldenEye 007 Saved James Bond - Movie Review
52.7K6 -
14:54
Mr Reagan
1 day ago $0.46 earnedWE ARE ALL MAGA NOW
44K100 -
15:35
Space Ice
23 hours ago'The Beekeeper' Exposes The Dark, Gritty, & Violent World Of Apiculture - Best Movie Ever
45K22 -
3:29:53
SonnyFaz
1 day agoEric Kelly Trains Sonny FULL STREAM
46.7K12