Proven lab leaks
Accidentally on purpose
https://dictionary.cambridge.org/dictionary/english/accidentally-on-purpose
WEF prepares for Disease X
Laboratory-acquired infections and pathogen escapes worldwide between 2000 and 2021
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00319-1/fulltext
Laboratory-acquired infections (LAIs),
and accidental pathogen escape from laboratory settings (APELS),
are major concerns for the community.
A risk-based approach for pathogen research management,
within a standard biosafety management framework is recommended,
but is challenging.
due to reasons such as inconsistency,
in risk tolerance and perception.
Here, we performed a scoping review,
using publicly available, peer-reviewed journal and media reports,
of LAIs and instances of APELS between 2000 and 2021.
Laboratory-acquired infections (LAIs)
309 individuals, 94 reports for 51 pathogens.
Eight fatalities
2·6% of all LAIs
Neisseria meningitidis (n=3, 37·5%)
Yersinia pestis (n=2, 25%)
Salmonella enterica serotype Typhimurium (n=1, 12·5%)
Ebola virus (n=1, 12·5%)
Bovine spongiform encephalopathy (n=1, 12·5%)
Accidental pathogen escape from laboratory settings (APELS)
16 APELS were reported
Bacillus anthracis (anthrax)
SARS-CoV
Poliovirus
Brucella spp (brucellosis zoonosis)
Foot and mouth disease virus
Influenza virus H5N1
Examples
the discovery of historical variola virus ampoules in cold storage during a move of laboratories at the National Institutes of Health campus in Bethesda, MD, USA in July, 2014
the shipment of live anthrax cultures from US Department of Defense laboratories following incomplete inactivation
Lethal Infection of Human ACE2-Transgenic Mice Caused by SARS-CoV-2- related Pangolin Coronavirus GX_P2V(short_3UTR)
https://www.biorxiv.org/content/10.1101/2024.01.03.574008v1.full.pdf
SARS-CoV-2-related pangolin coronavirus GX_P2V can cause 100% mortality in human ACE2-transgenic mice,
potentially attributable to late-stage brain infection.
This underscores a spillover risk of GX_P2V into humans
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